A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics

Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [(15)O] H(2)O/ CO(2) and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However...

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Autores principales: Kameyama, Masashi, Momose, Toshimitsu, Ishibashi, Kenji, Ishii, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841875/
https://www.ncbi.nlm.nih.gov/pubmed/35173665
http://dx.doi.org/10.3389/fneur.2021.765463
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author Kameyama, Masashi
Momose, Toshimitsu
Ishibashi, Kenji
Ishii, Kenji
author_facet Kameyama, Masashi
Momose, Toshimitsu
Ishibashi, Kenji
Ishii, Kenji
author_sort Kameyama, Masashi
collection PubMed
description Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [(15)O] H(2)O/ CO(2) and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV(2) is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future.
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spelling pubmed-88418752022-02-15 A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics Kameyama, Masashi Momose, Toshimitsu Ishibashi, Kenji Ishii, Kenji Front Neurol Neurology Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [(15)O] H(2)O/ CO(2) and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV(2) is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841875/ /pubmed/35173665 http://dx.doi.org/10.3389/fneur.2021.765463 Text en Copyright © 2022 Kameyama, Momose, Ishibashi and Ishii. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kameyama, Masashi
Momose, Toshimitsu
Ishibashi, Kenji
Ishii, Kenji
A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title_full A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title_fullStr A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title_full_unstemmed A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title_short A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics
title_sort novel proposal for an index for regional cerebral perfusion pressure – a theoretical approach using fluid dynamics
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841875/
https://www.ncbi.nlm.nih.gov/pubmed/35173665
http://dx.doi.org/10.3389/fneur.2021.765463
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