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Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this st...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841879/ https://www.ncbi.nlm.nih.gov/pubmed/35173572 http://dx.doi.org/10.3389/fnins.2021.768219 |
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author | Zhao, Hai-Chen Lv, Rui Zhang, Guang-Yu He, Le-Min Cai, Xiao-Tao Sun, Qiang Yan, Chun-Yan Bao, Xiang-Yuan Lv, Xin-Yue Fu, Bin |
author_facet | Zhao, Hai-Chen Lv, Rui Zhang, Guang-Yu He, Le-Min Cai, Xiao-Tao Sun, Qiang Yan, Chun-Yan Bao, Xiang-Yuan Lv, Xin-Yue Fu, Bin |
author_sort | Zhao, Hai-Chen |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this study is to investigate whether there exists a dysfunction of interactive information processing between the prefrontal cortex and posterior brain regions in ASD. We investigated the atypical connectivity and information flow between the prefrontal cortex and posterior brain regions in ASD utilizing the entropy connectivity (a kind of directional connectivity) method. Eighty-nine patients with ASD and 94 typical developing (TD) teenagers participated in this study. Two-sample t-tests revealed weakened interactive entropy connectivity between the prefrontal cortex and posterior brain regions. This result indicates that there exists interactive prefrontal-posterior underconnectivity in ASD, and this disorder might lead to less prior knowledge being used and updated. Our proposals highlighted that aforementioned atypical change might accelerate the deoptimization of brain networks in ASD. |
format | Online Article Text |
id | pubmed-8841879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88418792022-02-15 Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders Zhao, Hai-Chen Lv, Rui Zhang, Guang-Yu He, Le-Min Cai, Xiao-Tao Sun, Qiang Yan, Chun-Yan Bao, Xiang-Yuan Lv, Xin-Yue Fu, Bin Front Neurosci Neuroscience Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this study is to investigate whether there exists a dysfunction of interactive information processing between the prefrontal cortex and posterior brain regions in ASD. We investigated the atypical connectivity and information flow between the prefrontal cortex and posterior brain regions in ASD utilizing the entropy connectivity (a kind of directional connectivity) method. Eighty-nine patients with ASD and 94 typical developing (TD) teenagers participated in this study. Two-sample t-tests revealed weakened interactive entropy connectivity between the prefrontal cortex and posterior brain regions. This result indicates that there exists interactive prefrontal-posterior underconnectivity in ASD, and this disorder might lead to less prior knowledge being used and updated. Our proposals highlighted that aforementioned atypical change might accelerate the deoptimization of brain networks in ASD. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841879/ /pubmed/35173572 http://dx.doi.org/10.3389/fnins.2021.768219 Text en Copyright © 2022 Zhao, Lv, Zhang, He, Cai, Sun, Yan, Bao, Lv and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhao, Hai-Chen Lv, Rui Zhang, Guang-Yu He, Le-Min Cai, Xiao-Tao Sun, Qiang Yan, Chun-Yan Bao, Xiang-Yuan Lv, Xin-Yue Fu, Bin Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title_full | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title_fullStr | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title_full_unstemmed | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title_short | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
title_sort | alterations of prefrontal-posterior information processing patterns in autism spectrum disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841879/ https://www.ncbi.nlm.nih.gov/pubmed/35173572 http://dx.doi.org/10.3389/fnins.2021.768219 |
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