Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog

Adeno-associated virus (AAV) mediated gene therapy has been successfully applied in clinical trials, including hemophilia. Novel AAV vectors have been developed with enhanced transduction and specific tissue tropism. Considering the difference in efficacy of AAV transduction between animal models an...

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Detalles Bibliográficos
Autores principales: Shao, Wenwei, Sun, Junjiang, Chen, Xiaojing, Dobbins, Amanda, Merricks, Elizabeth P., Samulski, R. Jude, Nichols, Timothy C., Li, Chengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841897/
https://www.ncbi.nlm.nih.gov/pubmed/35173619
http://dx.doi.org/10.3389/fphar.2022.815317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841897/
https://www.ncbi.nlm.nih.gov/pubmed/35173619
http://dx.doi.org/10.3389/fphar.2022.815317

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