Cargando…
Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5
The EFSA Panel on Food Additives and Flavourings was requested to evaluate 55 flavouring substances assigned to the Flavouring Group Evaluation 07 (FGE.07), using the Procedure as outlined in the Commission Regulation (EC) No 1565/2000. Fifty‐three substances have already been considered in FGE.07 a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841967/ https://www.ncbi.nlm.nih.gov/pubmed/35198052 http://dx.doi.org/10.2903/j.efsa.2022.7090 |
_version_ | 1784650956793708544 |
---|---|
author | Younes, Maged Aquilina, Gabriele Castle, Laurence Engel, Karl‐Heinz Fowler, Paul J Frutos Fernandez, Maria Jose Fürst, Peter Gundert‐Remy, Ursula Gürtler, Rainer Husøy, Trine Manco, Melania Moldeus, Peter Passamonti, Sabina Shah, Romina Waalkens‐Berendsen, Ine Wölfle, Detlef Wright, Matthew Benigni, Romualdo Bolognesi, Claudia Chipman, Kevin Cordelli, Eugenia Degen, Gisela Marzin, Daniel Nørby, Karin Kristiane Svendsen, Camilla Vianello, Giorgia Mennes, Wim |
author_facet | Younes, Maged Aquilina, Gabriele Castle, Laurence Engel, Karl‐Heinz Fowler, Paul J Frutos Fernandez, Maria Jose Fürst, Peter Gundert‐Remy, Ursula Gürtler, Rainer Husøy, Trine Manco, Melania Moldeus, Peter Passamonti, Sabina Shah, Romina Waalkens‐Berendsen, Ine Wölfle, Detlef Wright, Matthew Benigni, Romualdo Bolognesi, Claudia Chipman, Kevin Cordelli, Eugenia Degen, Gisela Marzin, Daniel Nørby, Karin Kristiane Svendsen, Camilla Vianello, Giorgia Mennes, Wim |
collection | PubMed |
description | The EFSA Panel on Food Additives and Flavourings was requested to evaluate 55 flavouring substances assigned to the Flavouring Group Evaluation 07 (FGE.07), using the Procedure as outlined in the Commission Regulation (EC) No 1565/2000. Fifty‐three substances have already been considered in FGE.07 and its revisions. This revision 6 includes two additional substances which have been cleared with respect to genotoxicity in FGE.201Rev2 (4‐methyl‐3‐hepten‐5‐one [FL‐no: 07.261]) and FGE.204Rev1 (non‐2‐en‐4‐one, [FL‐no: 07.187]). The substances were evaluated through a stepwise approach that integrates information on the structure–activity relationships, intake from current uses, toxicological threshold of concern (TTC) and available data on metabolism and toxicity. The Panel concluded that none of the 55 substances gives rise to safety concerns at their levels of dietary intake, when estimated on the basis of the ‘Maximised Survey‐derived Daily Intake’ (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate. Normal and maximum use levels were available for all flavouring substances. For 52 substances, including the newly included substances [FL‐no: 07.187 and 07.261], their ‘modified Theoretical Added Maximum Daily Intakes’ (mTAMDIs) estimates were above the TTC for their structural classes (I and II). Therefore, for these 52 flavouring substances, more detailed data on uses and use levels should be provided to finalise their safety evaluations. |
format | Online Article Text |
id | pubmed-8841967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88419672022-02-22 Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 Younes, Maged Aquilina, Gabriele Castle, Laurence Engel, Karl‐Heinz Fowler, Paul J Frutos Fernandez, Maria Jose Fürst, Peter Gundert‐Remy, Ursula Gürtler, Rainer Husøy, Trine Manco, Melania Moldeus, Peter Passamonti, Sabina Shah, Romina Waalkens‐Berendsen, Ine Wölfle, Detlef Wright, Matthew Benigni, Romualdo Bolognesi, Claudia Chipman, Kevin Cordelli, Eugenia Degen, Gisela Marzin, Daniel Nørby, Karin Kristiane Svendsen, Camilla Vianello, Giorgia Mennes, Wim EFSA J Scientific Opinion The EFSA Panel on Food Additives and Flavourings was requested to evaluate 55 flavouring substances assigned to the Flavouring Group Evaluation 07 (FGE.07), using the Procedure as outlined in the Commission Regulation (EC) No 1565/2000. Fifty‐three substances have already been considered in FGE.07 and its revisions. This revision 6 includes two additional substances which have been cleared with respect to genotoxicity in FGE.201Rev2 (4‐methyl‐3‐hepten‐5‐one [FL‐no: 07.261]) and FGE.204Rev1 (non‐2‐en‐4‐one, [FL‐no: 07.187]). The substances were evaluated through a stepwise approach that integrates information on the structure–activity relationships, intake from current uses, toxicological threshold of concern (TTC) and available data on metabolism and toxicity. The Panel concluded that none of the 55 substances gives rise to safety concerns at their levels of dietary intake, when estimated on the basis of the ‘Maximised Survey‐derived Daily Intake’ (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate. Normal and maximum use levels were available for all flavouring substances. For 52 substances, including the newly included substances [FL‐no: 07.187 and 07.261], their ‘modified Theoretical Added Maximum Daily Intakes’ (mTAMDIs) estimates were above the TTC for their structural classes (I and II). Therefore, for these 52 flavouring substances, more detailed data on uses and use levels should be provided to finalise their safety evaluations. John Wiley and Sons Inc. 2022-02-14 /pmc/articles/PMC8841967/ /pubmed/35198052 http://dx.doi.org/10.2903/j.efsa.2022.7090 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Younes, Maged Aquilina, Gabriele Castle, Laurence Engel, Karl‐Heinz Fowler, Paul J Frutos Fernandez, Maria Jose Fürst, Peter Gundert‐Remy, Ursula Gürtler, Rainer Husøy, Trine Manco, Melania Moldeus, Peter Passamonti, Sabina Shah, Romina Waalkens‐Berendsen, Ine Wölfle, Detlef Wright, Matthew Benigni, Romualdo Bolognesi, Claudia Chipman, Kevin Cordelli, Eugenia Degen, Gisela Marzin, Daniel Nørby, Karin Kristiane Svendsen, Camilla Vianello, Giorgia Mennes, Wim Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title | Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title_full | Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title_fullStr | Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title_full_unstemmed | Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title_short | Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
title_sort | scientific opinion on flavouring group evaluation 7, revision 6 (fge.07rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841967/ https://www.ncbi.nlm.nih.gov/pubmed/35198052 http://dx.doi.org/10.2903/j.efsa.2022.7090 |
work_keys_str_mv | AT scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT younesmaged scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT aquilinagabriele scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT castlelaurence scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT engelkarlheinz scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT fowlerpaulj scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT frutosfernandezmariajose scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT furstpeter scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT gundertremyursula scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT gurtlerrainer scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT husøytrine scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT mancomelania scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT moldeuspeter scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT passamontisabina scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT shahromina scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT waalkensberendsenine scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT wolfledetlef scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT wrightmatthew scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT benigniromualdo scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT bolognesiclaudia scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT chipmankevin scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT cordellieugenia scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT degengisela scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT marzindaniel scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT nørbykarinkristiane scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT svendsencamilla scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT vianellogiorgia scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 AT menneswim scientificopiniononflavouringgroupevaluation7revision6fge07rev6saturatedandunsaturatedaliphaticsecondaryalcoholsketonesandestersofsecondaryalcoholsandsaturatedlinearorbranchedchaincarboxylicacidsfromchemicalgroup5 |