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Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases

PURPOSE: To evaluate the risk factors, medical and surgical management, and visual outcomes of patients affected by Acanthamoeba keratitis (AK) over a 16-year period. OBSERVATIONS: Records were reviewed retrospectively for all AK patients treated at University of Iowa between 2002 and 2017. Main out...

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Autores principales: Scruggs, Brittni A., Quist, Tyler S., Zimmerman, M. Bridget, Salinas, Jorge L., Greiner, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842025/
https://www.ncbi.nlm.nih.gov/pubmed/35198803
http://dx.doi.org/10.1016/j.ajoc.2022.101372
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author Scruggs, Brittni A.
Quist, Tyler S.
Zimmerman, M. Bridget
Salinas, Jorge L.
Greiner, Mark A.
author_facet Scruggs, Brittni A.
Quist, Tyler S.
Zimmerman, M. Bridget
Salinas, Jorge L.
Greiner, Mark A.
author_sort Scruggs, Brittni A.
collection PubMed
description PURPOSE: To evaluate the risk factors, medical and surgical management, and visual outcomes of patients affected by Acanthamoeba keratitis (AK) over a 16-year period. OBSERVATIONS: Records were reviewed retrospectively for all AK patients treated at University of Iowa between 2002 and 2017. Main outcomes measured were risk factors, time to diagnosis, coinfection types, initial and final visual acuities, and treatment outcomes, with failure of medical therapy defined as need for therapeutic keratoplasty (TK). Effects of steroid use on these outcomes were determined. Among all AK cases occurring during the study period (N = 110), the median age of the AK cohort was 31 years (range 8–80 years), and 49.1% were men. Contact lens wear was the primary risk factor for AK (95/100, 86.4%), and the median time to diagnosis was 0.70 (0.23–1.23) months. Forty-four AK patients (40%) failed medical therapy. Vision outcomes were better for AK patients with successful medical therapy compared to those requiring TK (LogMAR 0.00 v. 0.30; p < 0.0001). Corticosteroid use was associated with increased time to diagnosis (1.00 v. 0.50 months; p = 0.002), decreased final vision (LogMAR 0.10 v. 0.00; p < 0.05) and increased need for TK (40/77 v. 4/33; p < 0.001). CONCLUSIONS AND IMPORTANCE: Acanthamoeba keratitis cases have increased over the past two decades at our institution. In this large retrospective study, AK was commonly misdiagnosed with delayed diagnosis and high rates of failed medical therapy. Corticosteroid use before AK diagnosis led to poorer outcomes. Our findings underscore the need for ophthalmologists to suspect Acanthamoeba in the setting of contact lens-associated keratitis before topical steroids are initiated.
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spelling pubmed-88420252022-02-22 Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases Scruggs, Brittni A. Quist, Tyler S. Zimmerman, M. Bridget Salinas, Jorge L. Greiner, Mark A. Am J Ophthalmol Case Rep Case Report PURPOSE: To evaluate the risk factors, medical and surgical management, and visual outcomes of patients affected by Acanthamoeba keratitis (AK) over a 16-year period. OBSERVATIONS: Records were reviewed retrospectively for all AK patients treated at University of Iowa between 2002 and 2017. Main outcomes measured were risk factors, time to diagnosis, coinfection types, initial and final visual acuities, and treatment outcomes, with failure of medical therapy defined as need for therapeutic keratoplasty (TK). Effects of steroid use on these outcomes were determined. Among all AK cases occurring during the study period (N = 110), the median age of the AK cohort was 31 years (range 8–80 years), and 49.1% were men. Contact lens wear was the primary risk factor for AK (95/100, 86.4%), and the median time to diagnosis was 0.70 (0.23–1.23) months. Forty-four AK patients (40%) failed medical therapy. Vision outcomes were better for AK patients with successful medical therapy compared to those requiring TK (LogMAR 0.00 v. 0.30; p < 0.0001). Corticosteroid use was associated with increased time to diagnosis (1.00 v. 0.50 months; p = 0.002), decreased final vision (LogMAR 0.10 v. 0.00; p < 0.05) and increased need for TK (40/77 v. 4/33; p < 0.001). CONCLUSIONS AND IMPORTANCE: Acanthamoeba keratitis cases have increased over the past two decades at our institution. In this large retrospective study, AK was commonly misdiagnosed with delayed diagnosis and high rates of failed medical therapy. Corticosteroid use before AK diagnosis led to poorer outcomes. Our findings underscore the need for ophthalmologists to suspect Acanthamoeba in the setting of contact lens-associated keratitis before topical steroids are initiated. Elsevier 2022-01-27 /pmc/articles/PMC8842025/ /pubmed/35198803 http://dx.doi.org/10.1016/j.ajoc.2022.101372 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Scruggs, Brittni A.
Quist, Tyler S.
Zimmerman, M. Bridget
Salinas, Jorge L.
Greiner, Mark A.
Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title_full Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title_fullStr Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title_full_unstemmed Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title_short Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases
title_sort risk factors, management, and outcomes of acanthamoeba keratitis: a retrospective analysis of 110 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842025/
https://www.ncbi.nlm.nih.gov/pubmed/35198803
http://dx.doi.org/10.1016/j.ajoc.2022.101372
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