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Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles
[Image: see text] When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of 24 hybrids. Hybrids derived...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842223/ https://www.ncbi.nlm.nih.gov/pubmed/35084852 http://dx.doi.org/10.1021/acs.jmedchem.1c01807 |