Cargando…

Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles

[Image: see text] When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of 24 hybrids. Hybrids derived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elias, Rebecca, Basu, Pallabita, Fridman, Micha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842223/ https://www.ncbi.nlm.nih.gov/pubmed/35084852 http://dx.doi.org/10.1021/acs.jmedchem.1c01807

Ejemplares similares

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species
por: Tan, Jingwen, et al.
Publicado: (2021)

Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
por: Denardi, Laura Bedin, et al.
Publicado: (2015)

Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality
por: Bibi, Maayan, et al.
Publicado: (2021)

An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs
por: Wiedman, Gregory R., et al.
Publicado: (2017)

New Antifungal Agents with Azole Moieties
por: Teixeira, Melissa Martins, et al.
Publicado: (2022)

Synergistic Antifungal Effect of Glabridin and Fluconazole
por: Liu, Wei, et al.
Publicado: (2014)

Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates
por: Kubiça, Thaís Felli, et al.
Publicado: (2016)

Antifungal Activity and Synergism with Azoles of Polish Propolis
por: Gucwa, Katarzyna, et al.
Publicado: (2018)

Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor
por: Cam, Van Tran, et al.
Publicado: (2019)

618. Fluconazole-Resistant Candida albicans Vaginitis with Cross-Resistance to Azoles: A Case Report
por: Akdağ, Damla, et al.
Publicado: (2019)

Protease inhibitors and azolic antifungals in HIV patients with histoplasmosis: a clinical pharmacokinetics perspective
por: Okumura, Lucas Miyake
Publicado: (2016)

Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox
por: Kane, Aidan, et al.
Publicado: (2022)

Antifungal azoles – new antidote for chronic pelvic pain?
por: Dybowski, Bartosz
Publicado: (2013)

Detecting Azole-Antifungal Resistance in Aspergillus fumigatus by Pyrosequencing
por: van der Torre, Mireille H., et al.
Publicado: (2020)

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles
por: Shinde, Ravikumar Bapurao, et al.
Publicado: (2013)

Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis
por: Mayandi, Venkatesh, et al.
Publicado: (2023)

Recommendations on the use of azole antifungals in hematology-oncology patients
por: Azanza, José Ramón, et al.
Publicado: (2023)

Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole
por: Fonseca Bezerra, Camila, et al.
Publicado: (2020)

Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?
por: Verweij, Paul E., et al.
Publicado: (2016)

Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida albicans, Candida tropicalis, and Fluconazole-Resistant Strains
por: Lo, Wei-Hsuan, et al.
Publicado: (2020)

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
por: Yan, Zhimin, et al.
Publicado: (2012)

Recent Increase in the Prevalence of Fluconazole-Non-susceptible Candida tropicalis Blood Isolates in Turkey: Clinical Implication of Azole-Non-susceptible and Fluconazole Tolerant Phenotypes and Genotyping
por: Arastehfar, Amir, et al.
Publicado: (2020)

Proton pump inhibitors act synergistically with fluconazole against resistant Candida albicans
por: Lu, Mengjiao, et al.
Publicado: (2020)

Sterol uptake and sterol biosynthesis act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress
por: Li, Qingdi Quentin, et al.
Publicado: (2018)

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection
por: Colley, Thomas, et al.
Publicado: (2017)

Post-antifungal effect of the combination of anidulafungin with amphotericin B and fluconazole against fluconazole-susceptible and -resistant Candida albicans
por: Vaseghi, Narges, et al.
Publicado: (2022)

Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump
por: Xu, Jiali, et al.
Publicado: (2019)

Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans
por: Sharifzadeh, Aghil, et al.
Publicado: (2016)

Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis
por: Paul, Saikat, et al.
Publicado: (2022)

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles
por: Hu, Chengcheng, et al.
Publicado: (2018)

Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity
por: Li-Zhulanov, Nikolai S., et al.
Publicado: (2023)

Deletion of cox7c Results in Pan-Azole Resistance in Aspergillus fumigatus
por: Chen, Mingcong, et al.
Publicado: (2022)

Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia
por: Yu, Donghui T, et al.
Publicado: (2006)

Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species
por: Nagayoshi, Yohsuke, et al.
Publicado: (2017)

Triazole derivatives with improved in vitro antifungal activity over azole drugs
por: Yu, Shichong, et al.
Publicado: (2014)

In Vitro Activity of the Antifungal Azoles Itraconazole and Posaconazole against Leishmania amazonensis
por: de Macedo-Silva, Sara Teixeira, et al.
Publicado: (2013)

De-repression of CSP-1 activates adaptive responses to antifungal azoles
por: Chen, Xi, et al.
Publicado: (2016)

Mycoremediation of azole antifungal agents using in vitro cultures of Lentinula edodes
por: Kryczyk-Poprawa, Agata, et al.
Publicado: (2019)

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?
por: Berger, Sarah, et al.
Publicado: (2017)

Clinical analysis of the effects of azole antifungal agents on the anticoagulant activity of warfarin
por: Chen, Wenjun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_37f3n99ukdud080p4978o021ug