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Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles

[Image: see text] When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of 24 hybrids. Hybrids derived...

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Detalles Bibliográficos
Autores principales: Elias, Rebecca, Basu, Pallabita, Fridman, Micha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842223/
https://www.ncbi.nlm.nih.gov/pubmed/35084852
http://dx.doi.org/10.1021/acs.jmedchem.1c01807

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