Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A(1) Antagonists

[Image: see text] We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A(1)AR ligands. The most attractive ligands were confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and...

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Detalles Bibliográficos
Autores principales: Val, Cristina, Rodríguez-García, Carlos, Prieto-Díaz, Rubén, Crespo, Abel, Azuaje, Jhonny, Carbajales, Carlos, Majellaro, Maria, Díaz-Holguín, Alejandro, Brea, José M., Loza, Maria Isabel, Gioé-Gallo, Claudia, Contino, Marialessandra, Stefanachi, Angela, García-Mera, Xerardo, Estévez, Juan C., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842224/
https://www.ncbi.nlm.nih.gov/pubmed/35068155
http://dx.doi.org/10.1021/acs.jmedchem.1c01636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842224/
https://www.ncbi.nlm.nih.gov/pubmed/35068155
http://dx.doi.org/10.1021/acs.jmedchem.1c01636

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