Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells

[Image: see text] The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF tautomerase active site interfere with its biological activity. In contrast, the lack of potent MIF2 inhibitors...

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Detalles Bibliográficos
Autores principales: Xiao, Zhangping, Osipyan, Angelina, Song, Shanshan, Chen, Deng, Schut, Reinder A., van Merkerk, Ronald, van der Wouden, Petra E., Cool, Robbert H., Quax, Wim J., Melgert, Barbro N., Poelarends, Gerrit J., Dekker, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842245/
https://www.ncbi.nlm.nih.gov/pubmed/35041425
http://dx.doi.org/10.1021/acs.jmedchem.1c01598

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