In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas

[Image: see text] A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. The structure–activity relationships of a recently disc...

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Detalles Bibliográficos
Autores principales: Ottavi, Samantha, Scarry, Sarah M., Mosior, John, Ling, Yan, Roberts, Julia, Singh, Amrita, Zhang, David, Goullieux, Laurent, Roubert, Christine, Bacqué, Eric, Lagiakos, H. Rachel, Vendome, Jeremie, Moraca, Francesca, Li, Kelin, Perkowski, Andrew J., Ramesh, Remya, Bowler, Matthew M., Tracy, William, Feher, Victoria A., Sacchettini, James C., Gold, Ben S., Nathan, Carl F., Aubé, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842310/
https://www.ncbi.nlm.nih.gov/pubmed/35044775
http://dx.doi.org/10.1021/acs.jmedchem.1c01565

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