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Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2
Monitoring the mutation and evolution of the virus is important for tracing its ongoing transmission and facilitating effective vaccine development. A total of 342 complete genomic sequences of SARS-CoV-2 were analyzed in this study. Compared to the reference genome reported in December 2019, 465 mu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842338/ https://www.ncbi.nlm.nih.gov/pubmed/35173405 http://dx.doi.org/10.1177/1176934320954870 |
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author | Yu, Jie-Mei Zhang, Li-Shu Fu, Yuan-Hui Ji, Feng-Min Xu, Han-Li Huang, Jia-Qiang Peng, Xiang-Lei Zheng, Yan-Peng Zhang, Ying He, Jin-Sheng |
author_facet | Yu, Jie-Mei Zhang, Li-Shu Fu, Yuan-Hui Ji, Feng-Min Xu, Han-Li Huang, Jia-Qiang Peng, Xiang-Lei Zheng, Yan-Peng Zhang, Ying He, Jin-Sheng |
author_sort | Yu, Jie-Mei |
collection | PubMed |
description | Monitoring the mutation and evolution of the virus is important for tracing its ongoing transmission and facilitating effective vaccine development. A total of 342 complete genomic sequences of SARS-CoV-2 were analyzed in this study. Compared to the reference genome reported in December 2019, 465 mutations were found, among which, 347 occurred in only 1 sequence, while 26 occurred in more than 5 sequences. For these 26 further identified as SNPs, 14 were closely linked and were grouped into 5 profiles. Phylogenetic analysis revealed the sequences formed 2 major groups. Most of the sequences in late period (March and April) constituted the Cluster II, while the sequences before March in this study and the reported S/L and A/B/C types in previous studies were all in Cluster I. The distributions of some mutations were specific geographically or temporally, the potential effect of which on the transmission and pathogenicity of SARS-CoV-2 deserves further evaluation and monitoring. Two mutations were found in the receptor-binding domain (RBD) but outside the receptor-binding motif (RBM), indicating that mutations may only have marginal biological effects but merit further attention. The observed novel sequence divergence is of great significance to the study of the transmission, pathogenicity, and development of an effective vaccine for SARS-CoV-2. |
format | Online Article Text |
id | pubmed-8842338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-88423382022-02-15 Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 Yu, Jie-Mei Zhang, Li-Shu Fu, Yuan-Hui Ji, Feng-Min Xu, Han-Li Huang, Jia-Qiang Peng, Xiang-Lei Zheng, Yan-Peng Zhang, Ying He, Jin-Sheng Evol Bioinform Online Original Research Monitoring the mutation and evolution of the virus is important for tracing its ongoing transmission and facilitating effective vaccine development. A total of 342 complete genomic sequences of SARS-CoV-2 were analyzed in this study. Compared to the reference genome reported in December 2019, 465 mutations were found, among which, 347 occurred in only 1 sequence, while 26 occurred in more than 5 sequences. For these 26 further identified as SNPs, 14 were closely linked and were grouped into 5 profiles. Phylogenetic analysis revealed the sequences formed 2 major groups. Most of the sequences in late period (March and April) constituted the Cluster II, while the sequences before March in this study and the reported S/L and A/B/C types in previous studies were all in Cluster I. The distributions of some mutations were specific geographically or temporally, the potential effect of which on the transmission and pathogenicity of SARS-CoV-2 deserves further evaluation and monitoring. Two mutations were found in the receptor-binding domain (RBD) but outside the receptor-binding motif (RBM), indicating that mutations may only have marginal biological effects but merit further attention. The observed novel sequence divergence is of great significance to the study of the transmission, pathogenicity, and development of an effective vaccine for SARS-CoV-2. SAGE Publications 2020-10-01 /pmc/articles/PMC8842338/ /pubmed/35173405 http://dx.doi.org/10.1177/1176934320954870 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Yu, Jie-Mei Zhang, Li-Shu Fu, Yuan-Hui Ji, Feng-Min Xu, Han-Li Huang, Jia-Qiang Peng, Xiang-Lei Zheng, Yan-Peng Zhang, Ying He, Jin-Sheng Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title | Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title_full | Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title_fullStr | Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title_full_unstemmed | Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title_short | Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
title_sort | analysis of continuous mutation and evolution on circulating sars-cov-2 |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842338/ https://www.ncbi.nlm.nih.gov/pubmed/35173405 http://dx.doi.org/10.1177/1176934320954870 |
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