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A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect

BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally...

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Autores principales: Ranđelović, Sara, Bipat, Robbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842344/
https://www.ncbi.nlm.nih.gov/pubmed/35173509
http://dx.doi.org/10.1177/11795514211042023
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author Ranđelović, Sara
Bipat, Robbert
author_facet Ranđelović, Sara
Bipat, Robbert
author_sort Ranđelović, Sara
collection PubMed
description BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally derived and synthetic molecules with a wide variety of biological actions. The most common application of these molecules in medicine is for their thrombostatic activity. This study aims to give an overview of the current knowledge about the applicability of these chemical products in the therapeutic strategy against diabetes and its complications. METHODS: For this purpose, we searched internet databases for publications and abstracts in English that investigated the effects of coumarins or coumarin-like agents with potential anti-diabetic activity. RESULTS: The result is that a variety of these agents have proven in in vitro, in silico, and simple animal models to possess properties that may reduce the glucose absorption rate in the intestines, increase the level of insulin, increase the cellular uptake of glucose or reduce the gluconeogenesis. In addition, some of these agents also reduced the level of glycation of peptides in diabetic animal models and showed antioxidant properties. CONCLUSION: In conclusion, we can summarize that coumarins and their related derivatives may be potential antidiabetic agents. Useful formulations with appropriate pharmacokinetic and pharmacodynamic properties must be developed and tested for their efficacy and toxicity in comprehensive animal models before they can enter clinical trials.
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spelling pubmed-88423442022-02-15 A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect Ranđelović, Sara Bipat, Robbert Clin Med Insights Endocrinol Diabetes Review Article BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally derived and synthetic molecules with a wide variety of biological actions. The most common application of these molecules in medicine is for their thrombostatic activity. This study aims to give an overview of the current knowledge about the applicability of these chemical products in the therapeutic strategy against diabetes and its complications. METHODS: For this purpose, we searched internet databases for publications and abstracts in English that investigated the effects of coumarins or coumarin-like agents with potential anti-diabetic activity. RESULTS: The result is that a variety of these agents have proven in in vitro, in silico, and simple animal models to possess properties that may reduce the glucose absorption rate in the intestines, increase the level of insulin, increase the cellular uptake of glucose or reduce the gluconeogenesis. In addition, some of these agents also reduced the level of glycation of peptides in diabetic animal models and showed antioxidant properties. CONCLUSION: In conclusion, we can summarize that coumarins and their related derivatives may be potential antidiabetic agents. Useful formulations with appropriate pharmacokinetic and pharmacodynamic properties must be developed and tested for their efficacy and toxicity in comprehensive animal models before they can enter clinical trials. SAGE Publications 2021-09-14 /pmc/articles/PMC8842344/ /pubmed/35173509 http://dx.doi.org/10.1177/11795514211042023 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Ranđelović, Sara
Bipat, Robbert
A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title_full A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title_fullStr A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title_full_unstemmed A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title_short A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
title_sort review of coumarins and coumarin-related compounds for their potential antidiabetic effect
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842344/
https://www.ncbi.nlm.nih.gov/pubmed/35173509
http://dx.doi.org/10.1177/11795514211042023
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