Cargando…
A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect
BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842344/ https://www.ncbi.nlm.nih.gov/pubmed/35173509 http://dx.doi.org/10.1177/11795514211042023 |
_version_ | 1784651030619750400 |
---|---|
author | Ranđelović, Sara Bipat, Robbert |
author_facet | Ranđelović, Sara Bipat, Robbert |
author_sort | Ranđelović, Sara |
collection | PubMed |
description | BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally derived and synthetic molecules with a wide variety of biological actions. The most common application of these molecules in medicine is for their thrombostatic activity. This study aims to give an overview of the current knowledge about the applicability of these chemical products in the therapeutic strategy against diabetes and its complications. METHODS: For this purpose, we searched internet databases for publications and abstracts in English that investigated the effects of coumarins or coumarin-like agents with potential anti-diabetic activity. RESULTS: The result is that a variety of these agents have proven in in vitro, in silico, and simple animal models to possess properties that may reduce the glucose absorption rate in the intestines, increase the level of insulin, increase the cellular uptake of glucose or reduce the gluconeogenesis. In addition, some of these agents also reduced the level of glycation of peptides in diabetic animal models and showed antioxidant properties. CONCLUSION: In conclusion, we can summarize that coumarins and their related derivatives may be potential antidiabetic agents. Useful formulations with appropriate pharmacokinetic and pharmacodynamic properties must be developed and tested for their efficacy and toxicity in comprehensive animal models before they can enter clinical trials. |
format | Online Article Text |
id | pubmed-8842344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-88423442022-02-15 A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect Ranđelović, Sara Bipat, Robbert Clin Med Insights Endocrinol Diabetes Review Article BACKGROUND AND AIMS: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally derived and synthetic molecules with a wide variety of biological actions. The most common application of these molecules in medicine is for their thrombostatic activity. This study aims to give an overview of the current knowledge about the applicability of these chemical products in the therapeutic strategy against diabetes and its complications. METHODS: For this purpose, we searched internet databases for publications and abstracts in English that investigated the effects of coumarins or coumarin-like agents with potential anti-diabetic activity. RESULTS: The result is that a variety of these agents have proven in in vitro, in silico, and simple animal models to possess properties that may reduce the glucose absorption rate in the intestines, increase the level of insulin, increase the cellular uptake of glucose or reduce the gluconeogenesis. In addition, some of these agents also reduced the level of glycation of peptides in diabetic animal models and showed antioxidant properties. CONCLUSION: In conclusion, we can summarize that coumarins and their related derivatives may be potential antidiabetic agents. Useful formulations with appropriate pharmacokinetic and pharmacodynamic properties must be developed and tested for their efficacy and toxicity in comprehensive animal models before they can enter clinical trials. SAGE Publications 2021-09-14 /pmc/articles/PMC8842344/ /pubmed/35173509 http://dx.doi.org/10.1177/11795514211042023 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Ranđelović, Sara Bipat, Robbert A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title | A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title_full | A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title_fullStr | A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title_full_unstemmed | A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title_short | A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect |
title_sort | review of coumarins and coumarin-related compounds for their potential antidiabetic effect |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842344/ https://www.ncbi.nlm.nih.gov/pubmed/35173509 http://dx.doi.org/10.1177/11795514211042023 |
work_keys_str_mv | AT ranđelovicsara areviewofcoumarinsandcoumarinrelatedcompoundsfortheirpotentialantidiabeticeffect AT bipatrobbert areviewofcoumarinsandcoumarinrelatedcompoundsfortheirpotentialantidiabeticeffect AT ranđelovicsara reviewofcoumarinsandcoumarinrelatedcompoundsfortheirpotentialantidiabeticeffect AT bipatrobbert reviewofcoumarinsandcoumarinrelatedcompoundsfortheirpotentialantidiabeticeffect |