Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature...

Descripción completa

Detalles Bibliográficos
Autores principales: McDowell, Colleen M., Kizhatil, Krishnakumar, Elliott, Michael H., Overby, Darryl R., van Batenburg-Sherwood, Joseph, Millar, J. Cameron, Kuehn, Markus H., Zode, Gulab, Acott, Ted S., Anderson, Michael G., Bhattacharya, Sanjoy K., Bertrand, Jacques A., Borras, Terete, Bovenkamp, Diane E., Cheng, Lin, Danias, John, De Ieso, Michael Lucio, Du, Yiqin, Faralli, Jennifer A., Fuchshofer, Rudolf, Ganapathy, Preethi S., Gong, Haiyan, Herberg, Samuel, Hernandez, Humberto, Humphries, Peter, John, Simon W. M., Kaufman, Paul L., Keller, Kate E., Kelley, Mary J., Kelly, Ruth A., Krizaj, David, Kumar, Ajay, Leonard, Brian C., Lieberman, Raquel L., Liton, Paloma, Liu, Yutao, Liu, Katy C., Lopez, Navita N., Mao, Weiming, Mavlyutov, Timur, McDonnell, Fiona, McLellan, Gillian J., Mzyk, Philip, Nartey, Andrews, Pasquale, Louis R., Patel, Gaurang C., Pattabiraman, Padmanabhan P., Peters, Donna M., Raghunathan, Vijaykrishna, Rao, Ponugoti Vasantha, Rayana, Naga, Raychaudhuri, Urmimala, Reina-Torres, Ester, Ren, Ruiyi, Rhee, Douglas, Chowdhury, Uttio Roy, Samples, John R., Samples, E. Griffen, Sharif, Najam, Schuman, Joel S., Sheffield, Val C., Stevenson, Cooper H., Soundararajan, Avinash, Subramanian, Preeti, Sugali, Chenna Kesavulu, Sun, Yang, Toris, Carol B., Torrejon, Karen Y., Vahabikashi, Amir, Vranka, Janice A., Wang, Ting, Willoughby, Colin E., Xin, Chen, Yun, Hongmin, Zhang, Hao F., Fautsch, Michael P., Tamm, Ernst R., Clark, Abbot F., Ethier, C. Ross, Stamer, W. Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842499/
https://www.ncbi.nlm.nih.gov/pubmed/35129590
http://dx.doi.org/10.1167/iovs.63.2.12
Descripción
Sumario:Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Ejemplares similares