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The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents
BACKGROUND: Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. METHODS: We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842505/ https://www.ncbi.nlm.nih.gov/pubmed/35164680 http://dx.doi.org/10.1186/s12877-022-02779-0 |
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author | Soldevila, Laura Prat, Núria Mas, Miquel À. Massot, Mireia Miralles, Ramón Bonet-Simó, Josep M. Isnard, Mar Expósito-Izquierdo, Marta Garcia-Sanchez, Irene Rodoreda-Noguerola, Sara Moreno, Nemesio Badia, Esther López, Genís Sevilla, Javier Estrada, Oriol Vallès, Xavier |
author_facet | Soldevila, Laura Prat, Núria Mas, Miquel À. Massot, Mireia Miralles, Ramón Bonet-Simó, Josep M. Isnard, Mar Expósito-Izquierdo, Marta Garcia-Sanchez, Irene Rodoreda-Noguerola, Sara Moreno, Nemesio Badia, Esther López, Genís Sevilla, Javier Estrada, Oriol Vallès, Xavier |
author_sort | Soldevila, Laura |
collection | PubMed |
description | BACKGROUND: Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. METHODS: We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death. RESULTS: A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P < .001), higher community incidence (pooled aOR 1.67, P = .04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P = .03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P < .001), age (pooled aOR 1.16; P < .001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P < .001), Complex Chronic Condition (aOR 1.29, P < .001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P < .001). CONCLUSIONS: Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents. |
format | Online Article Text |
id | pubmed-8842505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88425052022-02-16 The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents Soldevila, Laura Prat, Núria Mas, Miquel À. Massot, Mireia Miralles, Ramón Bonet-Simó, Josep M. Isnard, Mar Expósito-Izquierdo, Marta Garcia-Sanchez, Irene Rodoreda-Noguerola, Sara Moreno, Nemesio Badia, Esther López, Genís Sevilla, Javier Estrada, Oriol Vallès, Xavier BMC Geriatr Research BACKGROUND: Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. METHODS: We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death. RESULTS: A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P < .001), higher community incidence (pooled aOR 1.67, P = .04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P = .03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P < .001), age (pooled aOR 1.16; P < .001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P < .001), Complex Chronic Condition (aOR 1.29, P < .001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P < .001). CONCLUSIONS: Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents. BioMed Central 2022-02-14 /pmc/articles/PMC8842505/ /pubmed/35164680 http://dx.doi.org/10.1186/s12877-022-02779-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Soldevila, Laura Prat, Núria Mas, Miquel À. Massot, Mireia Miralles, Ramón Bonet-Simó, Josep M. Isnard, Mar Expósito-Izquierdo, Marta Garcia-Sanchez, Irene Rodoreda-Noguerola, Sara Moreno, Nemesio Badia, Esther López, Genís Sevilla, Javier Estrada, Oriol Vallès, Xavier The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title | The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title_full | The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title_fullStr | The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title_full_unstemmed | The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title_short | The interplay between infection risk factors of SARS-CoV-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
title_sort | interplay between infection risk factors of sars-cov-2 and mortality: a cross-sectional study from a cohort of long-term care nursing home residents |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842505/ https://www.ncbi.nlm.nih.gov/pubmed/35164680 http://dx.doi.org/10.1186/s12877-022-02779-0 |
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