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O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

BACKGROUND: Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common cancer in men, and androgen-ablation therapy halts disease progression. However...

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Detalles Bibliográficos
Autores principales:	Gondane, Aishwarya, Girmay, Samuel, Helevä, Alma, Pallasaho, Satu, Loda, Massimo, Itkonen, Harri M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842528/ https://www.ncbi.nlm.nih.gov/pubmed/35164752 http://dx.doi.org/10.1186/s12929-022-00795-1

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