Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation

The most common inherited cause of two genetically and clinico-pathologically overlapping neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), is the presence of expanded GGGGCC intronic hexanucleotide repeats in the C9orf72 gene. Aside from haploinsuffi...

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Detalles Bibliográficos
Autores principales: Liu, Feilin, Morderer, Dmytro, Wren, Melissa C., Vettleson-Trutza, Sara A., Wang, Yanzhe, Rabichow, Benjamin E., Salemi, Michelle R., Phinney, Brett S., Oskarsson, Björn, Dickson, Dennis W., Rossoll, Wilfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842533/
https://www.ncbi.nlm.nih.gov/pubmed/35164882
http://dx.doi.org/10.1186/s40478-022-01322-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842533/
https://www.ncbi.nlm.nih.gov/pubmed/35164882
http://dx.doi.org/10.1186/s40478-022-01322-x

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