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Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects

PURPOSE: To analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time. METHODS: The CA status of 10 patients with NTG, 8 patients wit...

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Autores principales: Hamarat, Yasin, Deimantavicius, Mantas, Dambrauskas, Vilius, Labunskas, Vaidas, Putnynaite, Vilma, Lucinskas, Paulius, Siaudvytyte, Lina, Simiene, Evelina, Stoskuviene, Akvile, Januleviciene, Ingrida, Petkus, Vytautas, Ragauskas, Arminas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842541/
https://www.ncbi.nlm.nih.gov/pubmed/35138342
http://dx.doi.org/10.1167/tvst.11.2.17
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author Hamarat, Yasin
Deimantavicius, Mantas
Dambrauskas, Vilius
Labunskas, Vaidas
Putnynaite, Vilma
Lucinskas, Paulius
Siaudvytyte, Lina
Simiene, Evelina
Stoskuviene, Akvile
Januleviciene, Ingrida
Petkus, Vytautas
Ragauskas, Arminas
author_facet Hamarat, Yasin
Deimantavicius, Mantas
Dambrauskas, Vilius
Labunskas, Vaidas
Putnynaite, Vilma
Lucinskas, Paulius
Siaudvytyte, Lina
Simiene, Evelina
Stoskuviene, Akvile
Januleviciene, Ingrida
Petkus, Vytautas
Ragauskas, Arminas
author_sort Hamarat, Yasin
collection PubMed
description PURPOSE: To analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time. METHODS: The CA status of 10 patients with NTG, 8 patients with HTG, and 10 healthy subjects was assessed, using an innovative noninvasive ultrasonic technique, based on intracranial blood volume slow-wave measurements. Identified in each participant were intraocular pressure, ocular perfusion pressure, and CA-related parameter volumetric reactivity index (VRx), as well as the duration and doses of the longest cerebral autoregulation impairment (LCAI). In addition, we calculated the associations of these parameters with patients’ diagnoses. RESULTS: The VRx value, the LCAI dose, and duration in healthy subjects were significantly lower than in patients with NTG (P < 0.05). However, no significant differences were noted in these parameters between healthy subjects and HTG and between NTG and HTG groups. CONCLUSIONS: NTG is associated with the disturbed cerebral blood flow and could be diagnosed by performing noninvasive CA assessments. TRANSLATIONAL RELEVANCE: The VRx monitoring method can be applied to a wider range of patient groups, especially patients with normal-tension glaucoma.
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spelling pubmed-88425412022-02-18 Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects Hamarat, Yasin Deimantavicius, Mantas Dambrauskas, Vilius Labunskas, Vaidas Putnynaite, Vilma Lucinskas, Paulius Siaudvytyte, Lina Simiene, Evelina Stoskuviene, Akvile Januleviciene, Ingrida Petkus, Vytautas Ragauskas, Arminas Transl Vis Sci Technol Article PURPOSE: To analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time. METHODS: The CA status of 10 patients with NTG, 8 patients with HTG, and 10 healthy subjects was assessed, using an innovative noninvasive ultrasonic technique, based on intracranial blood volume slow-wave measurements. Identified in each participant were intraocular pressure, ocular perfusion pressure, and CA-related parameter volumetric reactivity index (VRx), as well as the duration and doses of the longest cerebral autoregulation impairment (LCAI). In addition, we calculated the associations of these parameters with patients’ diagnoses. RESULTS: The VRx value, the LCAI dose, and duration in healthy subjects were significantly lower than in patients with NTG (P < 0.05). However, no significant differences were noted in these parameters between healthy subjects and HTG and between NTG and HTG groups. CONCLUSIONS: NTG is associated with the disturbed cerebral blood flow and could be diagnosed by performing noninvasive CA assessments. TRANSLATIONAL RELEVANCE: The VRx monitoring method can be applied to a wider range of patient groups, especially patients with normal-tension glaucoma. The Association for Research in Vision and Ophthalmology 2022-02-09 /pmc/articles/PMC8842541/ /pubmed/35138342 http://dx.doi.org/10.1167/tvst.11.2.17 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Hamarat, Yasin
Deimantavicius, Mantas
Dambrauskas, Vilius
Labunskas, Vaidas
Putnynaite, Vilma
Lucinskas, Paulius
Siaudvytyte, Lina
Simiene, Evelina
Stoskuviene, Akvile
Januleviciene, Ingrida
Petkus, Vytautas
Ragauskas, Arminas
Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title_full Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title_fullStr Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title_full_unstemmed Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title_short Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects
title_sort prospective pilot clinical study of noninvasive cerebrovascular autoregulation monitoring in open-angle glaucoma patients and healthy subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842541/
https://www.ncbi.nlm.nih.gov/pubmed/35138342
http://dx.doi.org/10.1167/tvst.11.2.17
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