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The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats

PURPOSE: CMC 2.24, a chemically modified curcumin, was developed as a novel, pleiotropic MMP-inhibitor to treat various inflammatory/collagenolytic diseases including periodontitis. To date, this compound has shown efficacy in vitro, in cell culture, and in vivo (oral administration) in mice, rats a...

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Detalles Bibliográficos
Autores principales:	Bhatt, Heta Dinesh, McClain, Steve A, Lee, Hsi-Ming, Zimmerman, Thomas, Deng, Jie, Johnson, Francis, Gu, Ying, Golub, Lorne M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842656/ https://www.ncbi.nlm.nih.gov/pubmed/35173493 http://dx.doi.org/10.2147/JEP.S341927

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