Cargando…

Adverse Effects of Vemurafenib on Skin Integrity: Hyperkeratosis and Skin Cancer Initiation Due to Altered MEK/ERK-Signaling and MMP Activity

The BRAF inhibitor vemurafenib, approved for treating patients with BRAF V600E-mutant and unresectable or metastatic melanomas, rapidly induces cutaneous adverse events, including hyperkeratotic skin lesions and cutaneous squamous cell carcinomas (cSCC). To determine, how vemurafenib would provoke t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tham, Marius, Stark, Hans-Jürgen, Jauch, Anna, Harwood, Catherine, Pavez Lorie, Elizabeth, Boukamp, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842679/ https://www.ncbi.nlm.nih.gov/pubmed/35174094 http://dx.doi.org/10.3389/fonc.2022.827985

Ejemplares similares

Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw
por: Pavez Lorie, Elizabeth, et al.
Publicado: (2020)

RASopathic Skin Eruptions during Vemurafenib Therapy
por: Rinderknecht, Jeannine D., et al.
Publicado: (2013)

Complex Decongestive Physiotherapy Treats Skin Changes like Hyperkeratosis Caused by Lymphedema
por: Kaba, Hande, et al.
Publicado: (2012)

Targeting MEK in vemurafenib-resistant hairy cell leukemia
por: Caeser, Rebecca, et al.
Publicado: (2018)

Correction: RASopathic Skin Eruptions during Vemurafenib Therapy
por: Rinderknecht, Jeannine D., et al.
Publicado: (2013)

Congenital Hyperkeratosis
por: Foggie, W. E.
Publicado: (1922)

Unilateral nipple hyperkeratosis
por: Shah, Nehal, et al.
Publicado: (2019)

Chronic Venous Insufficiency and Lymphedema With Papillomatosis Cutis Lymphostatica, Hyperkeratosis, and Skin Ulcers: A Case Report
por: Senanayake, Jayani, et al.
Publicado: (2023)

Dermoscopic assessment of skin toxicities in patients with melanoma during treatment with vemurafenib
por: Rajczykowski, Marcin, et al.
Publicado: (2018)

An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs
por: Larribère, Lionel, et al.
Publicado: (2017)

Epidermolytic Hyperkeratosis - case report
por: Hayashida, Marcos Takeyoshi, et al.
Publicado: (2015)

Epidermolytic hyperkeratosis: clinical update
por: Peter Rout, Denice, et al.
Publicado: (2019)

Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer
por: Ding, Chenbo, et al.
Publicado: (2016)

Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone
por: Zhou, Hong, et al.
Publicado: (2023)

Ocular Changes in Metastatic Melanoma Patients Treated with MEK Inhibitor Cobimetinib and BRAF Inhibitor Vemurafenib
por: Gavric, Ana Ursula, et al.
Publicado: (2018)

The MEK1/2 Inhibitor AZD6244 Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib
por: Song, Hao, et al.
Publicado: (2018)

Chronic Arsenic Exposure and Oxidative Stress: OGG1 Expression and Arsenic Exposure, Nail Selenium, and Skin Hyperkeratosis in Inner Mongolia
por: Mo, Jinyao, et al.
Publicado: (2006)

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis
por: Lozano-Gerona, Javier, et al.
Publicado: (2020)

Surgical Approach for Nevoid Hyperkeratosis of the Areola
por: Foustanos, Andreas, et al.
Publicado: (2012)

Topical Selenium Sulfide for the Treatment of Hyperkeratosis
por: Cohen, Philip R., et al.
Publicado: (2018)

Vemurafenib and cutaneous adverse events - report of five cases
por: Silva, Giselle de Barros, et al.
Publicado: (2015)

XL888 limits vemurafenib-induced proliferative skin events by suppressing paradoxical MAPK activation
por: Phadke, Manali, et al.
Publicado: (2015)

Skin toxicity in BRAF(V600) mutated metastatic cutaneous melanoma patients treated with vemurafenib
por: Nowara, Elzbieta, et al.
Publicado: (2016)

Imaging markers of response to combined BRAF and MEK inhibition in BRAF mutated vemurafenib-sensitive and resistant melanomas
por: Acciardo, Stefania, et al.
Publicado: (2018)

Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer
por: Hu, Man, et al.
Publicado: (2020)

Retracted: The MEK1/2 Inhibitor AZD6244 Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib
por: Song, Hao, et al.
Publicado: (2022)

Nipple Hyperkeratosis Due to Malassezia Furfur Showing Excellent Response to Itraconazole
por: Parimalam, Kumar, et al.
Publicado: (2015)

Abstract 37: Lipotransfer Effectively Reverses Skin Fibrosis In Scleroderma In The Long Term Mediated Through MEK-Erk Signalling Pathways
por: Griffin, Michelle, et al.
Publicado: (2020)

Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway
por: Li, Tianyi, et al.
Publicado: (2023)

Antimicrobial peptide-producing dermal preadipocytes defend against Candida albicans skin infection via the FGFR-MEK-ERK pathway
por: Wang, Jianing, et al.
Publicado: (2023)

Hyperkeratosis and Frictional Dermatitis from Practicing Kendo
por: Yoshida, Masuki, et al.
Publicado: (2010)

Bilateral sole hyperkeratosis and nonhealing foot mass
por: Schneider, Samantha L., et al.
Publicado: (2018)

Dermoscopic Features of Nevoid Hyperkeratosis of the Nipple and Areola
por: Claudio, Conforti, et al.
Publicado: (2022)

Exaggerated hyperkeratosis in a nursing home patient
por: Zhu, Caroline, et al.
Publicado: (2022)

Incidental Cutaneous Reaction Patterns: Epidermolytic Hyperkeratosis, Acantholytic Dyskeratosis, and Hailey-Hailey-Like Acantholysis: A Potential Marker of Premalignant Skin Change
por: Gaertner, Erich M.
Publicado: (2011)

Correction for: Lycorine induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer
por: Hu, Man, et al.
Publicado: (2020)

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin
por: Zigrino, Paola, et al.
Publicado: (2016)

EPIDERMOLYTIC HYPERKERATOSIS IN INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVUS
por: Meibodi, Naser Tayyebi, et al.
Publicado: (2011)

Nevoid Hyperkeratosis of the Nipple and/or Areola: Treatment with Topical Steroid
por: Ghanadan, Alireza, et al.
Publicado: (2013)

Hyperkeratosis as a clue to diagnosis in a patient with myopathy
por: Cebeci, Ayşe Nurcan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_btao165j0d90ht7khe2dh2suh8