Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review

BACKGROUND: Poorly differentiated thyroid cancer (PDTC) is now classified as a separate thyroid tumor entity. It has male predominance and poor prognosis compared to differentiated TC. CASE: We report a case of a patient with PDTC who was previously deemed inoperable. A trial of neoadjuvant lenvatin...

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Autores principales: Alshehri, Khalid, Alqurashi, Yousuf, Merdad, Mazin, Samargandy, Shaza, Daghistani, Razan, Marzouki, Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842697/
https://www.ncbi.nlm.nih.gov/pubmed/34105309
http://dx.doi.org/10.1002/cnr2.1466
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author Alshehri, Khalid
Alqurashi, Yousuf
Merdad, Mazin
Samargandy, Shaza
Daghistani, Razan
Marzouki, Hani
author_facet Alshehri, Khalid
Alqurashi, Yousuf
Merdad, Mazin
Samargandy, Shaza
Daghistani, Razan
Marzouki, Hani
author_sort Alshehri, Khalid
collection PubMed
description BACKGROUND: Poorly differentiated thyroid cancer (PDTC) is now classified as a separate thyroid tumor entity. It has male predominance and poor prognosis compared to differentiated TC. CASE: We report a case of a patient with PDTC who was previously deemed inoperable. A trial of neoadjuvant lenvatinib therapy was given to the patient after that the tumor become operable and the surgery went successfully. CONCLUSIONS: Lenvatinib is a feasible option in patients with inoperable TC and can stabilize the lesion size or even reduce it, leading to a more favorable surgical outcome.
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spelling pubmed-88426972022-02-24 Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review Alshehri, Khalid Alqurashi, Yousuf Merdad, Mazin Samargandy, Shaza Daghistani, Razan Marzouki, Hani Cancer Rep (Hoboken) Case Report BACKGROUND: Poorly differentiated thyroid cancer (PDTC) is now classified as a separate thyroid tumor entity. It has male predominance and poor prognosis compared to differentiated TC. CASE: We report a case of a patient with PDTC who was previously deemed inoperable. A trial of neoadjuvant lenvatinib therapy was given to the patient after that the tumor become operable and the surgery went successfully. CONCLUSIONS: Lenvatinib is a feasible option in patients with inoperable TC and can stabilize the lesion size or even reduce it, leading to a more favorable surgical outcome. John Wiley and Sons Inc. 2021-06-08 /pmc/articles/PMC8842697/ /pubmed/34105309 http://dx.doi.org/10.1002/cnr2.1466 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alshehri, Khalid
Alqurashi, Yousuf
Merdad, Mazin
Samargandy, Shaza
Daghistani, Razan
Marzouki, Hani
Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title_full Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title_fullStr Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title_full_unstemmed Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title_short Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review
title_sort neoadjuvant lenvatinib for inoperable thyroid cancer: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842697/
https://www.ncbi.nlm.nih.gov/pubmed/34105309
http://dx.doi.org/10.1002/cnr2.1466
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