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Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201

BACKGROUND AND PURPOSE: Lipid mediators (LM) play crucial roles in the complex inflammation process with respect to initiation, maintenance, and resolution. Proinflammatory leukotrienes (LTs), generated by 5-lipoxygenase (LOX) and the 5-LOX-activating protein (FLAP), initiate and maintain inflammati...

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Detalles Bibliográficos
Autores principales:	Kretzer, Christian, Jordan, Paul M, Bilancia, Rossella, Rossi, Antonietta, Gür Maz, Tuğçe, Banoglu, Erden, Schubert, Ulrich S, Werz, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842732/ https://www.ncbi.nlm.nih.gov/pubmed/35173459 http://dx.doi.org/10.2147/JIR.S345510

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