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Quantitative Gradient Echo MRI Identifies Dark Matter as a New Imaging Biomarker of Neurodegeneration that Precedes Tissue Atrophy in Early Alzheimer’s Disease

BACKGROUND: Currently, brain tissue atrophy serves as an in vivo MRI biomarker of neurodegeneration in Alzheimer’s disease (AD). However, postmortem histopathological studies show that neuronal loss in AD exceeds volumetric loss of tissue and that loss of memory in AD begins when neurons and synapse...

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Detalles Bibliográficos
Autores principales:	Kothapalli, Satya V.V.N., Benzinger, Tammie L., Aschenbrenner, Andrew J., Perrin, Richard J., Hildebolt, Charles F., Goyal, Manu S., Fagan, Anne M., Raichle, Marcus E., Morris, John C., Yablonskiy, Dmitriy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842777/ https://www.ncbi.nlm.nih.gov/pubmed/34897083 http://dx.doi.org/10.3233/JAD-210503

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