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Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemod...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842780/ https://www.ncbi.nlm.nih.gov/pubmed/34806632 http://dx.doi.org/10.3233/THC-219002 |
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author | Petuchova, Aleksandra Maknickas, Algirdas |
author_facet | Petuchova, Aleksandra Maknickas, Algirdas |
author_sort | Petuchova, Aleksandra |
collection | PubMed |
description | BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemodynamic parameters of an ascending aorta and ascending aortic aneurysm in humans. METHODS: Two aortic models were constructed from medical images using the SimVascular software. FEM blood flow modelling of cardiac cycle was performed using CFD and CMM-FSI at different vascular wall parameters. RESULTS: The results showed that highest blood velocity was 1.18 m/s in aorta with the aneurysm and 1.9 m/s in healthy aorta model. The largest displacements ware in the aorta with the aneurysm (0.73 mm). In the aorta with the aneurysm, time averaged WSS values throughout the artery range from 0 Pa to 1 Pa. In the healthy aorta, distribution of WSS values changes from 0.3 Pa to 0.6 Pa. CONCLUSIONS: In the case of an ascending aortic aneurysm, the maximum blood velocity was found to be 1.6 times lower than in the healthy aorta. The aneurysm-based model demonstrates a 45% greater wall displacement, while the oscillatory shear index decreased by 30% compared to healthy aortic results. |
format | Online Article Text |
id | pubmed-8842780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88427802022-03-02 Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm Petuchova, Aleksandra Maknickas, Algirdas Technol Health Care Research Article BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemodynamic parameters of an ascending aorta and ascending aortic aneurysm in humans. METHODS: Two aortic models were constructed from medical images using the SimVascular software. FEM blood flow modelling of cardiac cycle was performed using CFD and CMM-FSI at different vascular wall parameters. RESULTS: The results showed that highest blood velocity was 1.18 m/s in aorta with the aneurysm and 1.9 m/s in healthy aorta model. The largest displacements ware in the aorta with the aneurysm (0.73 mm). In the aorta with the aneurysm, time averaged WSS values throughout the artery range from 0 Pa to 1 Pa. In the healthy aorta, distribution of WSS values changes from 0.3 Pa to 0.6 Pa. CONCLUSIONS: In the case of an ascending aortic aneurysm, the maximum blood velocity was found to be 1.6 times lower than in the healthy aorta. The aneurysm-based model demonstrates a 45% greater wall displacement, while the oscillatory shear index decreased by 30% compared to healthy aortic results. IOS Press 2021-12-29 /pmc/articles/PMC8842780/ /pubmed/34806632 http://dx.doi.org/10.3233/THC-219002 Text en © 2022 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Petuchova, Aleksandra Maknickas, Algirdas Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title | Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title_full | Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title_fullStr | Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title_full_unstemmed | Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title_short | Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
title_sort | computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842780/ https://www.ncbi.nlm.nih.gov/pubmed/34806632 http://dx.doi.org/10.3233/THC-219002 |
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