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Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm

BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemod...

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Detalles Bibliográficos
Autores principales: Petuchova, Aleksandra, Maknickas, Algirdas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842780/
https://www.ncbi.nlm.nih.gov/pubmed/34806632
http://dx.doi.org/10.3233/THC-219002
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author Petuchova, Aleksandra
Maknickas, Algirdas
author_facet Petuchova, Aleksandra
Maknickas, Algirdas
author_sort Petuchova, Aleksandra
collection PubMed
description BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemodynamic parameters of an ascending aorta and ascending aortic aneurysm in humans. METHODS: Two aortic models were constructed from medical images using the SimVascular software. FEM blood flow modelling of cardiac cycle was performed using CFD and CMM-FSI at different vascular wall parameters. RESULTS: The results showed that highest blood velocity was 1.18 m/s in aorta with the aneurysm and 1.9 m/s in healthy aorta model. The largest displacements ware in the aorta with the aneurysm (0.73 mm). In the aorta with the aneurysm, time averaged WSS values throughout the artery range from 0 Pa to 1 Pa. In the healthy aorta, distribution of WSS values changes from 0.3 Pa to 0.6 Pa. CONCLUSIONS: In the case of an ascending aortic aneurysm, the maximum blood velocity was found to be 1.6 times lower than in the healthy aorta. The aneurysm-based model demonstrates a 45% greater wall displacement, while the oscillatory shear index decreased by 30% compared to healthy aortic results.
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spelling pubmed-88427802022-03-02 Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm Petuchova, Aleksandra Maknickas, Algirdas Technol Health Care Research Article BACKGROUND: The usefulness of numerical modelling of a patient’s cardiovascular system is growing in clinical treatment. Understanding blood flow mechanics can be crucial in identifying connections between haemodynamic factors and aortic wall pathologies. OBJECTIVE: This work investigates the haemodynamic parameters of an ascending aorta and ascending aortic aneurysm in humans. METHODS: Two aortic models were constructed from medical images using the SimVascular software. FEM blood flow modelling of cardiac cycle was performed using CFD and CMM-FSI at different vascular wall parameters. RESULTS: The results showed that highest blood velocity was 1.18 m/s in aorta with the aneurysm and 1.9 m/s in healthy aorta model. The largest displacements ware in the aorta with the aneurysm (0.73 mm). In the aorta with the aneurysm, time averaged WSS values throughout the artery range from 0 Pa to 1 Pa. In the healthy aorta, distribution of WSS values changes from 0.3 Pa to 0.6 Pa. CONCLUSIONS: In the case of an ascending aortic aneurysm, the maximum blood velocity was found to be 1.6 times lower than in the healthy aorta. The aneurysm-based model demonstrates a 45% greater wall displacement, while the oscillatory shear index decreased by 30% compared to healthy aortic results. IOS Press 2021-12-29 /pmc/articles/PMC8842780/ /pubmed/34806632 http://dx.doi.org/10.3233/THC-219002 Text en © 2022 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Petuchova, Aleksandra
Maknickas, Algirdas
Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title_full Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title_fullStr Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title_full_unstemmed Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title_short Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
title_sort computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842780/
https://www.ncbi.nlm.nih.gov/pubmed/34806632
http://dx.doi.org/10.3233/THC-219002
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