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Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network

Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to...

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Autores principales: Pavlik, Valory N., Burnham, Samantha C., Kass, Joseph S., Helmer, Catherine, Palmqvist, Sebastian, Vassilaki, Maria, Dartigues, Jean-François, Hansson, Oskar, Masters, Colin L., Pérès, Karine, Petersen, Ronald C., Stomrud, Erik, Butler, Lesley, Coloma, Preciosa M., Teitsma, Xavier M., Doody, Rachelle, Sano, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842789/
https://www.ncbi.nlm.nih.gov/pubmed/34776434
http://dx.doi.org/10.3233/JAD-210525
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author Pavlik, Valory N.
Burnham, Samantha C.
Kass, Joseph S.
Helmer, Catherine
Palmqvist, Sebastian
Vassilaki, Maria
Dartigues, Jean-François
Hansson, Oskar
Masters, Colin L.
Pérès, Karine
Petersen, Ronald C.
Stomrud, Erik
Butler, Lesley
Coloma, Preciosa M.
Teitsma, Xavier M.
Doody, Rachelle
Sano, Mary
author_facet Pavlik, Valory N.
Burnham, Samantha C.
Kass, Joseph S.
Helmer, Catherine
Palmqvist, Sebastian
Vassilaki, Maria
Dartigues, Jean-François
Hansson, Oskar
Masters, Colin L.
Pérès, Karine
Petersen, Ronald C.
Stomrud, Erik
Butler, Lesley
Coloma, Preciosa M.
Teitsma, Xavier M.
Doody, Rachelle
Sano, Mary
author_sort Pavlik, Valory N.
collection PubMed
description Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed.
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spelling pubmed-88427892022-03-02 Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network Pavlik, Valory N. Burnham, Samantha C. Kass, Joseph S. Helmer, Catherine Palmqvist, Sebastian Vassilaki, Maria Dartigues, Jean-François Hansson, Oskar Masters, Colin L. Pérès, Karine Petersen, Ronald C. Stomrud, Erik Butler, Lesley Coloma, Preciosa M. Teitsma, Xavier M. Doody, Rachelle Sano, Mary J Alzheimers Dis Review Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed. IOS Press 2022-01-04 /pmc/articles/PMC8842789/ /pubmed/34776434 http://dx.doi.org/10.3233/JAD-210525 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Pavlik, Valory N.
Burnham, Samantha C.
Kass, Joseph S.
Helmer, Catherine
Palmqvist, Sebastian
Vassilaki, Maria
Dartigues, Jean-François
Hansson, Oskar
Masters, Colin L.
Pérès, Karine
Petersen, Ronald C.
Stomrud, Erik
Butler, Lesley
Coloma, Preciosa M.
Teitsma, Xavier M.
Doody, Rachelle
Sano, Mary
Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title_full Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title_fullStr Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title_full_unstemmed Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title_short Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
title_sort connecting cohorts to diminish alzheimer’s disease (concord-ad): a report of an international research collaboration network
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842789/
https://www.ncbi.nlm.nih.gov/pubmed/34776434
http://dx.doi.org/10.3233/JAD-210525
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