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Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network
Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842789/ https://www.ncbi.nlm.nih.gov/pubmed/34776434 http://dx.doi.org/10.3233/JAD-210525 |
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author | Pavlik, Valory N. Burnham, Samantha C. Kass, Joseph S. Helmer, Catherine Palmqvist, Sebastian Vassilaki, Maria Dartigues, Jean-François Hansson, Oskar Masters, Colin L. Pérès, Karine Petersen, Ronald C. Stomrud, Erik Butler, Lesley Coloma, Preciosa M. Teitsma, Xavier M. Doody, Rachelle Sano, Mary |
author_facet | Pavlik, Valory N. Burnham, Samantha C. Kass, Joseph S. Helmer, Catherine Palmqvist, Sebastian Vassilaki, Maria Dartigues, Jean-François Hansson, Oskar Masters, Colin L. Pérès, Karine Petersen, Ronald C. Stomrud, Erik Butler, Lesley Coloma, Preciosa M. Teitsma, Xavier M. Doody, Rachelle Sano, Mary |
author_sort | Pavlik, Valory N. |
collection | PubMed |
description | Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed. |
format | Online Article Text |
id | pubmed-8842789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88427892022-03-02 Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network Pavlik, Valory N. Burnham, Samantha C. Kass, Joseph S. Helmer, Catherine Palmqvist, Sebastian Vassilaki, Maria Dartigues, Jean-François Hansson, Oskar Masters, Colin L. Pérès, Karine Petersen, Ronald C. Stomrud, Erik Butler, Lesley Coloma, Preciosa M. Teitsma, Xavier M. Doody, Rachelle Sano, Mary J Alzheimers Dis Review Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer’s disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed. IOS Press 2022-01-04 /pmc/articles/PMC8842789/ /pubmed/34776434 http://dx.doi.org/10.3233/JAD-210525 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Pavlik, Valory N. Burnham, Samantha C. Kass, Joseph S. Helmer, Catherine Palmqvist, Sebastian Vassilaki, Maria Dartigues, Jean-François Hansson, Oskar Masters, Colin L. Pérès, Karine Petersen, Ronald C. Stomrud, Erik Butler, Lesley Coloma, Preciosa M. Teitsma, Xavier M. Doody, Rachelle Sano, Mary Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title | Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title_full | Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title_fullStr | Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title_full_unstemmed | Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title_short | Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network |
title_sort | connecting cohorts to diminish alzheimer’s disease (concord-ad): a report of an international research collaboration network |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842789/ https://www.ncbi.nlm.nih.gov/pubmed/34776434 http://dx.doi.org/10.3233/JAD-210525 |
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