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Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report
BACKGROUND: Radical esophagectomy for esophageal squamous cell carcinoma has improved survival, but the rate of recurrence is high. Patients of recurrent esophageal squamous cell carcinoma after failure of chemotherapy have a poor prognosis. We herein report the achievement of long-term survival aft...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842904/ https://www.ncbi.nlm.nih.gov/pubmed/35152904 http://dx.doi.org/10.1186/s13256-022-03275-0 |
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author | Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao |
author_facet | Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao |
author_sort | Ishikawa, Yojiro |
collection | PubMed |
description | BACKGROUND: Radical esophagectomy for esophageal squamous cell carcinoma has improved survival, but the rate of recurrence is high. Patients of recurrent esophageal squamous cell carcinoma after failure of chemotherapy have a poor prognosis. We herein report the achievement of long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma after failure of chemotherapy. CASE PRESENTATION: A 60-year-old Japanese man was diagnosed as having squamous cell carcinoma of the lower thoracic esophagus (cT2N0M0, stage IIA). He underwent two courses of neoadjuvant chemotherapy with cisplatin and 5-fluorouracil, and esophagectomy with three-field lymphadenectomy was performed. Microscopic findings after resection showed two lymph node metastases (ypT2N1M0, stage IIB). Five months after resection, a computed tomography scan revealed a solitary liver metastasis in the S4 area. He underwent three courses of chemotherapy with cisplatin and 5-fluorouracil; however, positron emission tomography revealed two lymph node metastases. Surgeons recommended second-line chemotherapy, but the patient refused chemotherapy and requested proton beam therapy. We performed proton beam therapy without chemotherapy for the liver metastasis and lymph node metastases, with total doses of 79.2 and 60 Gy relative biological effectiveness, respectively, according to the tumor location. An acute side effect of grade 1 dermatitis occurred after proton beam therapy, but there was no acute or late complication of more than grade 2. The patient remains in complete remission 5 years after treatment without surgery or chemotherapy. DISCUSSION AND CONCLUSIONS: Proton beam therapy exerted a curative effect on oligorecurrent esophageal squamous cell carcinoma. This is the first report on the achievement of long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma. |
format | Online Article Text |
id | pubmed-8842904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88429042022-02-16 Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao J Med Case Rep Case Report BACKGROUND: Radical esophagectomy for esophageal squamous cell carcinoma has improved survival, but the rate of recurrence is high. Patients of recurrent esophageal squamous cell carcinoma after failure of chemotherapy have a poor prognosis. We herein report the achievement of long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma after failure of chemotherapy. CASE PRESENTATION: A 60-year-old Japanese man was diagnosed as having squamous cell carcinoma of the lower thoracic esophagus (cT2N0M0, stage IIA). He underwent two courses of neoadjuvant chemotherapy with cisplatin and 5-fluorouracil, and esophagectomy with three-field lymphadenectomy was performed. Microscopic findings after resection showed two lymph node metastases (ypT2N1M0, stage IIB). Five months after resection, a computed tomography scan revealed a solitary liver metastasis in the S4 area. He underwent three courses of chemotherapy with cisplatin and 5-fluorouracil; however, positron emission tomography revealed two lymph node metastases. Surgeons recommended second-line chemotherapy, but the patient refused chemotherapy and requested proton beam therapy. We performed proton beam therapy without chemotherapy for the liver metastasis and lymph node metastases, with total doses of 79.2 and 60 Gy relative biological effectiveness, respectively, according to the tumor location. An acute side effect of grade 1 dermatitis occurred after proton beam therapy, but there was no acute or late complication of more than grade 2. The patient remains in complete remission 5 years after treatment without surgery or chemotherapy. DISCUSSION AND CONCLUSIONS: Proton beam therapy exerted a curative effect on oligorecurrent esophageal squamous cell carcinoma. This is the first report on the achievement of long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma. BioMed Central 2022-02-14 /pmc/articles/PMC8842904/ /pubmed/35152904 http://dx.doi.org/10.1186/s13256-022-03275-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Ishikawa, Yojiro Suzuki, Motohisa Yamaguchi, Hisashi Seto, Ichiro Machida, Masanori Takagawa, Yoshiaki Jingu, Keiichi Kikuchi, Yasuyuki Murakami, Masao Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title | Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title_full | Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title_fullStr | Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title_full_unstemmed | Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title_short | Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
title_sort | long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842904/ https://www.ncbi.nlm.nih.gov/pubmed/35152904 http://dx.doi.org/10.1186/s13256-022-03275-0 |
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