Cargando…

Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

Clinical symptoms correlate with underlying neurodegenerative changes in the vast majority of people. However, an intriguing group of individuals demonstrate neuropathologic changes consistent with Alzheimer disease (AD) yet remain cognitively normal (termed “resilient”). Previous studies have repor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walker, Jamie M., Kazempour Dehkordi, Shiva, Fracassi, Anna, Vanschoiack, Alison, Pavenko, Anna, Taglialatela, Giulio, Woltjer, Randall, Richardson, Timothy E., Zare, Habil, Orr, Miranda E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842950/ https://www.ncbi.nlm.nih.gov/pubmed/35164877 http://dx.doi.org/10.1186/s40478-022-01324-9

Ejemplares similares

TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology
por: Fracassi, Anna, et al.
Publicado: (2022)

Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology
por: Fracassi, Anna, et al.
Publicado: (2021)

Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology
por: Zolochevska, Olga, et al.
Publicado: (2018)

Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
por: Singh, Ayush, et al.
Publicado: (2020)

Transcriptome Profiling in the Hippocampi of Mice with Experimental Autoimmune Encephalomyelitis
por: Weerasinghe-Mudiyanselage, Poornima D. E., et al.
Publicado: (2022)

Messenger RNA expression profiles and bioinformatics analysis of mouse hippocampi during exercise alleviates methamphetamine dependence via mRNA profile change in hippocampi
por: Li, Yue, et al.
Publicado: (2022)

Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer’s disease
por: Gonzales, Mitzi M., et al.
Publicado: (2023)

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn(2+) in cognitively intact aged individuals with Alzheimer’s disease neuropathology
por: Bjorklund, Nicole L, et al.
Publicado: (2012)

Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats☆
por: Ren, Guiru, et al.
Publicado: (2013)

Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease
por: Marcatti, Michela, et al.
Publicado: (2022)

Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer’s Disease Amyloid Beta Oligomers
por: Zolochevska, Olga, et al.
Publicado: (2020)

Asynchronous ripple oscillations between left and right hippocampi during slow-wave sleep
por: Villalobos, Claudio, et al.
Publicado: (2017)

Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer's disease
por: Ferreira, E, et al.
Publicado: (2016)

Age-related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats
por: LI, YALI, et al.
Publicado: (2016)

Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients
por: Wittner, Lucia, et al.
Publicado: (2017)

Dynamic Changes in Spectral and Spatial Signatures of High Frequency Oscillations in Rat Hippocampi during Epileptogenesis in Acute and Chronic Stages
por: Song, Pan-Pan, et al.
Publicado: (2016)

Glutamate and Lipid Metabolic Perturbation in the Hippocampi of Asymptomatic Borna Disease Virus-Infected Horses
por: Zhang, Liang, et al.
Publicado: (2014)

Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi
por: Nemoda, Z, et al.
Publicado: (2015)

Regional distribution of cytochrome c oxidase activity and copper in sclerotic hippocampi of epilepsy patients
por: Opačić, Miloš, et al.
Publicado: (2020)

Differential Gene Expression in the Hippocampi of Nonhuman Primates Chronically Exposed to Methamphetamine, Cocaine, or Heroin
por: Choi, Mi Ran, et al.
Publicado: (2022)

“iNETgrate”: integrating DNA methylation and gene expression data in a single gene network
por: Sajedi, Sogand, et al.
Publicado: (2023)

Preserved neurogenesis in non-demented individuals with AD neuropathology
por: Briley, David, et al.
Publicado: (2016)

Quantitative MR evaluation of atrophy, as well as perfusion and diffusion alterations within hippocampi in patients with Alzheimer’s disease and mild cognitive impairment
por: Zimny, Anna, et al.
Publicado: (2013)

Ultra-high field MRI of human hippocampi: Morphological and multiparametric differentiation of hippocampal sclerosis subtypes
por: Gillmann, Clarissa, et al.
Publicado: (2018)

Upregulation of aryl hydrocarbon receptor nuclear translocator 2 in the hippocampi of post-stroke depression rats
por: Pei, Chen-Di, et al.
Publicado: (2019)

Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
por: Elsner, Viviane Rostirola, et al.
Publicado: (2018)

Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process
por: Born, João Paulo Lopes, et al.
Publicado: (2017)

Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration
por: Choi, Mi Ran, et al.
Publicado: (2020)

Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1
por: Majewski, Lukasz, et al.
Publicado: (2019)

Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi
por: Luo, Si-si, et al.
Publicado: (2022)

Nucleospora hippocampi n. sp., an Intranuclear Microsporidian Infecting the Seahorse Hippocampus erectus From China
por: Wang, Yuan, et al.
Publicado: (2022)

Spatial Analysis of Neural Cell Proteomic Profiles Following Ischemic Stroke in Mice Using High-Plex Digital Spatial Profiling
por: Noll, Jessica M., et al.
Publicado: (2022)

Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2
por: Jung, Hyo Young, et al.
Publicado: (2021)

Slowly developing depression of N-methyl-D-aspartate receptor mediated responses in young rat hippocampi
por: Dozmorov, Mikhail, et al.
Publicado: (2004)

Light enough to travel: migratory bats have smaller brains, but not larger hippocampi, than sedentary species
por: McGuire, Liam P., et al.
Publicado: (2011)

Gene expression patterns and environmental enrichment-induced effects in the hippocampi of mice suggest importance of Lsamp in plasticity
por: Heinla, Indrek, et al.
Publicado: (2015)

Long-term Autophagy and Nrf2 Signaling in the Hippocampi of Developing Mice after Carbon Ion Exposure
por: Ye, Fei, et al.
Publicado: (2015)

Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease
por: HU, WANHUA, et al.
Publicado: (2015)

Draft Genome Sequence of Mycobacterium hippocampi DL, Isolated from European Sea Bass (Dicentrarchus labrax)
por: Stathopoulou, Panagiota, et al.
Publicado: (2020)

Interleukin-13 Propagates Prothrombin Kringle-2-Induced Neurotoxicity in Hippocampi In Vivo via Oxidative Stress
por: Jeong, Jae Yeong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_us1qp8r8v9era68ipb5f55fhnu