HP47 : Post covid optic neuritis,Egyptian two case reports

The exact incidence of neurological complications from coronavirus disease 2019 (COVID-19) infection remains unknown. Neurological symptoms are more common with severe form of the disease. Through neuro-invasion, the virus can affect both neurons and glial cells and induce wide range of neurological pathologies. CNS symptoms is commoner representing 91% of all neurological patients with 9% only with PNS. PNS manifestations showed variable results where visual impairment and nerve pains were more frequent in the severe COVID-19 category of patients. This is a 2 case report study of post covid optic neuritis , both after severe covid infection and hospitalization ,they developed acute onset visual affection mostly1.5 month in the first case and 2 month in the second one after almost complete cure. The first case had monocular delayed perception of vision , the second one had complete visual loss of one eye of unexplained causes. All neurological and ophthalmological investigations were normal apart from visual evoked potentials that showed small amplitude p100 response in the first case and absent response in the last one. This supports a study Based on murine models of other CoVs, stated that viral-induced optic neuritis secondary to autoantibody production against neuroretina should also be included in the differential diagnosis and infected patients should be monitored for signs of neuroretinal degeneration in the long term.