Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway

The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression and invasion. TAMs are polarized in situ to a tumo...

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Detalles Bibliográficos
Autores principales: Boyer, Seth, Lee, Ho-Joon, Steele, Nina, Zhang, Li, Sajjakulnukit, Peter, Andren, Anthony, Ward, Matthew H, Singh, Rima, Basrur, Venkatesha, Zhang, Yaqing, Nesvizhskii, Alexey I, Pasca di Magliano, Marina, Halbrook, Christopher J, Lyssiotis, Costas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843093/
https://www.ncbi.nlm.nih.gov/pubmed/35156921
http://dx.doi.org/10.7554/eLife.73796

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