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Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor
In the present study, via using a ligand featuring oxalamide groups N,N′-bis(4-phthalic acid) (H(4)L), two new Cu(II) and Co(II)-containing coordination polymers with the chemical formulae of [Cu(2)L(H(2)O)(4)](n) (1) and [Co(H(2)L)(H(2)O)(2)](n) (2) have been successfully prepared via reaction of t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843167/ https://www.ncbi.nlm.nih.gov/pubmed/35173523 http://dx.doi.org/10.1080/15685551.2022.2033432 |
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author | Zhao, Jin Du, Lan |
author_facet | Zhao, Jin Du, Lan |
author_sort | Zhao, Jin |
collection | PubMed |
description | In the present study, via using a ligand featuring oxalamide groups N,N′-bis(4-phthalic acid) (H(4)L), two new Cu(II) and Co(II)-containing coordination polymers with the chemical formulae of [Cu(2)L(H(2)O)(4)](n) (1) and [Co(H(2)L)(H(2)O)(2)](n) (2) have been successfully prepared via reaction of the corresponding metal salts with the H(4)L ligand. The as-prepared two coordination polymers have been studied via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction and thermogravimetric analysis. Their therapeutic effect and mechanism for ovarian cancer was evaluated and explored. Firstly, the inhibitory activity of the new compounds on the proliferation of the ovarian cancer was measured with CCK-8 assay after compound treatment. Besides, the relative expression of the estrogen receptor on the ovarian cancer cells after compound treatment was also determined with real-time RT-PCR assay. |
format | Online Article Text |
id | pubmed-8843167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88431672022-02-15 Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor Zhao, Jin Du, Lan Des Monomers Polym Full Length Article In the present study, via using a ligand featuring oxalamide groups N,N′-bis(4-phthalic acid) (H(4)L), two new Cu(II) and Co(II)-containing coordination polymers with the chemical formulae of [Cu(2)L(H(2)O)(4)](n) (1) and [Co(H(2)L)(H(2)O)(2)](n) (2) have been successfully prepared via reaction of the corresponding metal salts with the H(4)L ligand. The as-prepared two coordination polymers have been studied via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction and thermogravimetric analysis. Their therapeutic effect and mechanism for ovarian cancer was evaluated and explored. Firstly, the inhibitory activity of the new compounds on the proliferation of the ovarian cancer was measured with CCK-8 assay after compound treatment. Besides, the relative expression of the estrogen receptor on the ovarian cancer cells after compound treatment was also determined with real-time RT-PCR assay. Taylor & Francis 2022-02-09 /pmc/articles/PMC8843167/ /pubmed/35173523 http://dx.doi.org/10.1080/15685551.2022.2033432 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Length Article Zhao, Jin Du, Lan Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title | Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title_full | Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title_fullStr | Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title_full_unstemmed | Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title_short | Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
title_sort | therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843167/ https://www.ncbi.nlm.nih.gov/pubmed/35173523 http://dx.doi.org/10.1080/15685551.2022.2033432 |
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