Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express normal levels of the TRAF6 protein. Remarkably, TRA...

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Detalles Bibliográficos
Autores principales: Petrova, Tsvetana, Bennett, Kyle, Nanda, Sambit, Strickson, Sam, Scudamore, Cheryl L., Prescott, Alan R., Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843210/
https://www.ncbi.nlm.nih.gov/pubmed/35157702
http://dx.doi.org/10.1371/journal.pone.0263151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843210/
https://www.ncbi.nlm.nih.gov/pubmed/35157702
http://dx.doi.org/10.1371/journal.pone.0263151

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