Cargando…

Mitigation of SARS-CoV2-Mediated Endothelial Injury via Suppression of the Epigenetic Enzyme KMT2A/MLL1 in Macrophages

Detalles Bibliográficos
Autores principales:	Sharma, Sriganesh, Hawley, Angela, Melvin, William, Audu, Christopher, Kanthi, Yogendra, Knight, Jason, Adili, Raymond, Holinstat, Michael, Henke, Peter, Wakefield, Thomas, Gallagher, Katherine, Moore, Bethany, Obi, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Inc. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843428/ http://dx.doi.org/10.1016/j.jvsv.2021.12.009

Ejemplares similares

The Epigenetic Enzyme KMT2A/MLL1 Is a Driver of Coronavirus-associated Coagulopathy
por: Sharma, Sriganesh B., et al.
Publicado: (2022)

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
por: Sharma, Sriganesh B., et al.
Publicado: (2023)

MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and response to imatinib mesylate in chronic myeloid leukemia
por: Rabello, Doralina do Amaral, et al.
Publicado: (2018)

Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase
por: Klonou, Alexia, et al.
Publicado: (2021)

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions
por: Meyer, Claus, et al.
Publicado: (2019)

Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements
por: Tsakaneli, Alexia, et al.
Publicado: (2021)

Outcomes of acute lymphoblastic leukemia with KMT2A (MLL) rearrangement: the MD Anderson experience
por: Richard-Carpentier, Guillaume, et al.
Publicado: (2021)

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies
por: Cowell, Ian G., et al.
Publicado: (2023)

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
por: Hillman, R. Tyler, et al.
Publicado: (2018)

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer
por: Rampias, Theodoros, et al.
Publicado: (2019)

Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass
por: Bao, Haiyan, et al.
Publicado: (2019)

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors
por: Dhar, Shilpa S., et al.
Publicado: (2021)

Three de novo variants in KMT2A (MLL) identified by whole exome sequencing in patients with Wiedemann–Steiner syndrome
por: Luo, Sukun, et al.
Publicado: (2021)

Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements
por: Esposito, Maria Teresa, et al.
Publicado: (2022)

Tyrosine kinases in KMT2A/MLL-rearranged acute leukemias as potential therapeutic targets to overcome cancer drug resistance
por: Uckun, Fatih M., et al.
Publicado: (2022)

Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2
por: Melvin, William J., et al.
Publicado: (2021)

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
por: Ballabio, Erica, et al.
Publicado: (2012)

Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes
por: Wiersma, Maaike, et al.
Publicado: (2016)

Epigenetic regulation of the PGE(2) pathway modulates macrophage phenotype in normal and pathologic wound repair
por: Davis, Frank M., et al.
Publicado: (2020)

Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins
por: Ballabio, Erica, et al.
Publicado: (2014)

De Novo variants in the KMT2A (MLL) gene causing atypical Wiedemann-Steiner syndrome in two unrelated individuals identified by clinical exome sequencing
por: Strom, Samuel P, et al.
Publicado: (2014)

SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
por: Kumar, Nitin, et al.
Publicado: (2021)

Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome
por: Knight, Jason S., et al.
Publicado: (2022)

Regulation of IL-20 Expression by Estradiol through KMT2B-Mediated Epigenetic Modification
por: Su, Chia-Hsin, et al.
Publicado: (2016)

Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation
por: Huang, Yin-Cheng, et al.
Publicado: (2017)

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
por: Chan, Anthony K. N., et al.
Publicado: (2019)

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers
por: Stroynowska-Czerwinska, Anna Maria, et al.
Publicado: (2023)

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis
por: Milan, Thomas, et al.
Publicado: (2020)

A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements
por: Eberle, Julia, et al.
Publicado: (2021)

MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
por: Wu, Min, et al.
Publicado: (2011)

MLL1 promotes myogenesis by epigenetically regulating Myf5
por: Cai, Shufang, et al.
Publicado: (2019)

Pan-sarcoma genomic analysis of KMT2A rearrangements reveals distinct subtypes defined by YAP1–KMT2A–YAP1 and VIM–KMT2A fusions
por: Massoth, Lucas R., et al.
Publicado: (2020)

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95
por: Jiang, Hao, et al.
Publicado: (2013)

Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia
por: Cerveira, Nuno, et al.
Publicado: (2009)

Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance
por: Sun, Chi, et al.
Publicado: (2022)

Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma
por: López, Virginia, et al.
Publicado: (2021)

Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4
por: Lv, Shidong, et al.
Publicado: (2017)

Genetic and Epigenetic Characterization of a Discordant KMT2A/AFF1-Rearranged Infant Monozygotic Twin Pair
por: Russo, Alessia, et al.
Publicado: (2021)

Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients
por: ZHU, SHA, et al.
Publicado: (2023)

KMT2A: Umbrella Gene for Multiple Diseases
por: Castiglioni, Silvia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ohh2ot9s55t36hnak7knciq4o6