Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance

Many SARS-CoV-2 neutralizing antibodies (nAbs) lose potency against variants of concern. In this study, we developed 2 strategies to produce mutation-resistant antibodies. First, a yeast library expressing mutant receptor binding domains (RBDs) of the spike protein was utilized to screen for potent...

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Detalles Bibliográficos
Autores principales: Zou, Jia, Li, Li, Zheng, Peiyi, Liang, Wenhua, Hu, Siyi, Zhou, Shuaixiang, Wang, Yanqun, Zhao, Jincun, Yuan, Daopeng, Liu, Lu, Wu, Dongdong, Xu, Mengqiu, Zhang, Fangfang, Zhu, Mengzhu, Wu, Zhihai, Cao, Xiaochao, Ni, Meng, Ling, Xiaomin, Wu, Yue, Kuang, Zhihui, Hu, Moyan, Li, Jianfeng, Li, Xue, Guo, Xiling, Xu, Tianmin, Jiang, Haiping, Gao, Changshou, Yu, Michael, Liu, Junjian, Zhong, Nanshan, Zhou, Jianfeng, Huang, Jian-an, Jin, Tengchuan, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843702/
https://www.ncbi.nlm.nih.gov/pubmed/35108220
http://dx.doi.org/10.1172/JCI154987

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