Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility

Exposure to addictive substances impairs flexible decision making. Cognitive flexibility is mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking alters cognitive flexibility through CINs remains unclear. Here, we report that chronic alcohol consumption and with...

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Detalles Bibliográficos
Autores principales: Ma, Tengfei, Huang, Zhenbo, Xie, Xueyi, Cheng, Yifeng, Zhuang, Xiaowen, Childs, Matthew J., Gangal, Himanshu, Wang, Xuehua, Smith, Laura N., Smith, Rachel J., Zhou, Yubin, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843706/
https://www.ncbi.nlm.nih.gov/pubmed/34941575
http://dx.doi.org/10.1172/JCI154969

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