Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers

Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) could enable more effective a...

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Detalles Bibliográficos
Autores principales: Lim, Shion A., Zhou, Jie, Martinko, Alexander J., Wang, Yung-Hua, Filippova, Ekaterina V., Steri, Veronica, Wang, Donghui, Remesh, Soumya G., Liu, Jia, Hann, Byron, Kossiakoff, Anthony A., Evans, Michael J., Leung, Kevin K., Wells, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843743/
https://www.ncbi.nlm.nih.gov/pubmed/35166238
http://dx.doi.org/10.1172/JCI154604

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