Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation

The chromosomal t(4;14) (p16;q32) translocation drives high expression of histone methyltransferase nuclear SET domain–containing 2 (NSD2) and plays vital roles in multiple myeloma (MM) evolution and progression. However, the mechanisms of NSD2-driven epigenomic alterations in chemoresistance to pro...

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Detalles Bibliográficos
Autores principales: Wang, Jingjing, Zhu, Xu, Dang, Lin, Jiang, Hongmei, Xie, Ying, Li, Xin, Guo, Jing, Wang, Yixuan, Peng, Ziyi, Wang, Mengqi, Wang, Jingya, Wang, Sheng, Li, Qian, Wang, Yafei, Wang, Qiang, Ye, Lingqun, Zhang, Lirong, Liu, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843744/
https://www.ncbi.nlm.nih.gov/pubmed/35166240
http://dx.doi.org/10.1172/JCI149526

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