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Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions
Type 2 immunity is critical for the protective and repair responses that mediate resistance to parasitic helminth infection. This immune response also drives aberrant inflammation during atopic diseases. Prostaglandins are a class of critical lipid mediators that are released during type 2 inflammat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843787/ https://www.ncbi.nlm.nih.gov/pubmed/34396535 http://dx.doi.org/10.1002/eji.202048909 |
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author | Oyesola, Oyebola O. Tait Wojno, Elia D. |
author_facet | Oyesola, Oyebola O. Tait Wojno, Elia D. |
author_sort | Oyesola, Oyebola O. |
collection | PubMed |
description | Type 2 immunity is critical for the protective and repair responses that mediate resistance to parasitic helminth infection. This immune response also drives aberrant inflammation during atopic diseases. Prostaglandins are a class of critical lipid mediators that are released during type 2 inflammation and are integral in controlling the initiation, activation, maintenance, effector functions, and resolution of Type 2 inflammation. In this review, we explore the roles of the different prostaglandin family members and the receptors they bind to during allergen‐ and helminth‐induced Type 2 inflammation and the mechanism through which prostaglandins promote or suppress Type 2 inflammation. Furthermore, we discuss the potential role of prostaglandins produced by helminth parasites in the regulation of host–pathogen interactions, and how prostaglandins may regulate the inverse relationship between helminth infection and allergy. Finally, we discuss opportunities to capitalize on our understanding of prostaglandin pathways to develop new therapeutic options for humans experiencing Type 2 inflammatory disorders that have a significant prostaglandin‐driven component including allergic rhinitis and asthma. |
format | Online Article Text |
id | pubmed-8843787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88437872022-10-01 Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions Oyesola, Oyebola O. Tait Wojno, Elia D. Eur J Immunol Highlights Type 2 immunity is critical for the protective and repair responses that mediate resistance to parasitic helminth infection. This immune response also drives aberrant inflammation during atopic diseases. Prostaglandins are a class of critical lipid mediators that are released during type 2 inflammation and are integral in controlling the initiation, activation, maintenance, effector functions, and resolution of Type 2 inflammation. In this review, we explore the roles of the different prostaglandin family members and the receptors they bind to during allergen‐ and helminth‐induced Type 2 inflammation and the mechanism through which prostaglandins promote or suppress Type 2 inflammation. Furthermore, we discuss the potential role of prostaglandins produced by helminth parasites in the regulation of host–pathogen interactions, and how prostaglandins may regulate the inverse relationship between helminth infection and allergy. Finally, we discuss opportunities to capitalize on our understanding of prostaglandin pathways to develop new therapeutic options for humans experiencing Type 2 inflammatory disorders that have a significant prostaglandin‐driven component including allergic rhinitis and asthma. John Wiley and Sons Inc. 2021-09-07 2021-10 /pmc/articles/PMC8843787/ /pubmed/34396535 http://dx.doi.org/10.1002/eji.202048909 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Highlights Oyesola, Oyebola O. Tait Wojno, Elia D. Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title | Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title_full | Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title_fullStr | Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title_full_unstemmed | Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title_short | Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions |
title_sort | prostaglandin regulation of type 2 inflammation: from basic biology to therapeutic interventions |
topic | Highlights |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843787/ https://www.ncbi.nlm.nih.gov/pubmed/34396535 http://dx.doi.org/10.1002/eji.202048909 |
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