Hypercalciuria switches Ca(2+) signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis

Proximal tubule (PT) transports most of the renal Ca(2+), which was usually described as paracellular (passive). We found a regulated Ca(2+) entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates transcellular Ca(2+) transport. Although TRP...

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Detalles Bibliográficos
Autores principales: Shin, Samuel, Ibeh, Cliff-Lawrence, Awuah Boadi, Eugenia, Choi, Bok-Eum, Roy, Sanjit K., Bandyopadhyay, Bidhan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843860/
https://www.ncbi.nlm.nih.gov/pubmed/35224165
http://dx.doi.org/10.1016/j.gendis.2021.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843860/
https://www.ncbi.nlm.nih.gov/pubmed/35224165
http://dx.doi.org/10.1016/j.gendis.2021.04.006

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