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Hypercalciuria switches Ca(2+) signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis
Proximal tubule (PT) transports most of the renal Ca(2+), which was usually described as paracellular (passive). We found a regulated Ca(2+) entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates transcellular Ca(2+) transport. Although TRP...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chongqing Medical University
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843860/ https://www.ncbi.nlm.nih.gov/pubmed/35224165 http://dx.doi.org/10.1016/j.gendis.2021.04.006 |