Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) share several common pathophysiological features. Rare variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing AD, suggesting the involvement of TREM2 and innate immunity in AD development....

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Detalles Bibliográficos
Autores principales: Wu, Min, Liao, Maolin, Huang, Rongfeng, Chen, Chunxiu, Tian, Tian, Wang, Hongying, Li, Jiayu, Li, Jibin, Sun, Yuxiang, Wu, Chaodong, Li, Qifu, Xiao, Xiaoqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843863/
https://www.ncbi.nlm.nih.gov/pubmed/35224156
http://dx.doi.org/10.1016/j.gendis.2020.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843863/
https://www.ncbi.nlm.nih.gov/pubmed/35224156
http://dx.doi.org/10.1016/j.gendis.2020.05.005

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