Cargando…
Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity
Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal, multilineage differentiation, and immune regulation. MSCs have different cellular effects in different diseases, an...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843883/ https://www.ncbi.nlm.nih.gov/pubmed/35224147 http://dx.doi.org/10.1016/j.gendis.2020.10.006 |
_version_ | 1784651361656242176 |
---|---|
author | Tan, Liping Liu, Xuan Dou, Huan Hou, Yayi |
author_facet | Tan, Liping Liu, Xuan Dou, Huan Hou, Yayi |
author_sort | Tan, Liping |
collection | PubMed |
description | Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal, multilineage differentiation, and immune regulation. MSCs have different cellular effects in different diseases, and even have markedly different curative effects with different tissue sources, indicating the plasticity of MSCs. The phenotypes, secreted factors, and proliferative, migratory, differentiating, and immunomodulatory effects of MSCs depend on certain mediators present in their microenvironment. Understanding microenvironmental factors and their internal mechanisms in MSC responses may help in subsequent prediction and improvement of clinical benefits. This review highlighted the recent advances in MSC plasticity in the physiological and pathological microenvironment and multiple microenvironmental factors regulating MSC plasticity. It also highlighted some progress in the underlying molecular mechanisms of MSC remodeling in the microenvironment. It might provide references for the improvement in vitro culture of MSCs, clinical application, and in vivo induction. |
format | Online Article Text |
id | pubmed-8843883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-88438832022-02-25 Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity Tan, Liping Liu, Xuan Dou, Huan Hou, Yayi Genes Dis Review Article Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal, multilineage differentiation, and immune regulation. MSCs have different cellular effects in different diseases, and even have markedly different curative effects with different tissue sources, indicating the plasticity of MSCs. The phenotypes, secreted factors, and proliferative, migratory, differentiating, and immunomodulatory effects of MSCs depend on certain mediators present in their microenvironment. Understanding microenvironmental factors and their internal mechanisms in MSC responses may help in subsequent prediction and improvement of clinical benefits. This review highlighted the recent advances in MSC plasticity in the physiological and pathological microenvironment and multiple microenvironmental factors regulating MSC plasticity. It also highlighted some progress in the underlying molecular mechanisms of MSC remodeling in the microenvironment. It might provide references for the improvement in vitro culture of MSCs, clinical application, and in vivo induction. Chongqing Medical University 2020-10-27 /pmc/articles/PMC8843883/ /pubmed/35224147 http://dx.doi.org/10.1016/j.gendis.2020.10.006 Text en © 2020 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Tan, Liping Liu, Xuan Dou, Huan Hou, Yayi Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title_full | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title_fullStr | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title_full_unstemmed | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title_short | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity |
title_sort | characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of msc plasticity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843883/ https://www.ncbi.nlm.nih.gov/pubmed/35224147 http://dx.doi.org/10.1016/j.gendis.2020.10.006 |
work_keys_str_mv | AT tanliping characteristicsandregulationofmesenchymalstemcellplasticitybythemicroenvironmentspecificfactorsinvolvedintheregulationofmscplasticity AT liuxuan characteristicsandregulationofmesenchymalstemcellplasticitybythemicroenvironmentspecificfactorsinvolvedintheregulationofmscplasticity AT douhuan characteristicsandregulationofmesenchymalstemcellplasticitybythemicroenvironmentspecificfactorsinvolvedintheregulationofmscplasticity AT houyayi characteristicsandregulationofmesenchymalstemcellplasticitybythemicroenvironmentspecificfactorsinvolvedintheregulationofmscplasticity |