Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Chengyu, Gong, Lijing, Cui, Xiaoxu, Jönsson, Johanna, Zheng, Yunji, Wu, Chengjun, Kajitani, Naoko, Schwartz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843915/
https://www.ncbi.nlm.nih.gov/pubmed/34860285
http://dx.doi.org/10.1007/s00705-021-05317-2
_version_ 1784651368838987776
author Hao, Chengyu
Gong, Lijing
Cui, Xiaoxu
Jönsson, Johanna
Zheng, Yunji
Wu, Chengjun
Kajitani, Naoko
Schwartz, Stefan
author_facet Hao, Chengyu
Gong, Lijing
Cui, Xiaoxu
Jönsson, Johanna
Zheng, Yunji
Wu, Chengjun
Kajitani, Naoko
Schwartz, Stefan
author_sort Hao, Chengyu
collection PubMed
description We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-05317-2.
format Online
Article
Text
id pubmed-8843915
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-88439152022-02-23 Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing Hao, Chengyu Gong, Lijing Cui, Xiaoxu Jönsson, Johanna Zheng, Yunji Wu, Chengjun Kajitani, Naoko Schwartz, Stefan Arch Virol Brief Report We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-05317-2. Springer Vienna 2021-12-03 2022 /pmc/articles/PMC8843915/ /pubmed/34860285 http://dx.doi.org/10.1007/s00705-021-05317-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Hao, Chengyu
Gong, Lijing
Cui, Xiaoxu
Jönsson, Johanna
Zheng, Yunji
Wu, Chengjun
Kajitani, Naoko
Schwartz, Stefan
Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title_full Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title_fullStr Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title_full_unstemmed Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title_short Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing
title_sort identification of heterogenous nuclear ribonucleoproteins (hnrnps) and serine- and arginine-rich (sr) proteins that induce human papillomavirus type 16 late gene expression and alter l1 mrna splicing
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843915/
https://www.ncbi.nlm.nih.gov/pubmed/34860285
http://dx.doi.org/10.1007/s00705-021-05317-2
work_keys_str_mv AT haochengyu identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT gonglijing identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT cuixiaoxu identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT jonssonjohanna identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT zhengyunji identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT wuchengjun identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT kajitaninaoko identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing
AT schwartzstefan identificationofheterogenousnuclearribonucleoproteinshnrnpsandserineandargininerichsrproteinsthatinducehumanpapillomavirustype16lategeneexpressionandalterl1mrnasplicing

Ejemplares similares