Cargando…

Unraveling the Expression Patterns of Immune Checkpoints Identifies New Subtypes and Emerging Therapeutic Indicators in Lung Adenocarcinoma

Immune checkpoint genes (ICGs) play pivotal roles in tumor immune microenvironment (TIME), and thus, targeting them represents a promising strategy for cancer immunotherapy. However, the genetic landscape of ICGs in lung adenocarcinoma (LUAD) is still unknown. Herein, we comprehensively evaluated th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jinguo, Han, Xinghua, Lin, Lin, Chen, Jian, Wang, Feng, Ding, Qi, Hao, Li, Wang, Lingyu, Wei, Jie, Wang, Yong, Pan, Yueyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843963/ https://www.ncbi.nlm.nih.gov/pubmed/35178154 http://dx.doi.org/10.1155/2022/3583985

Ejemplares similares

Immune checkpoints expression patterns in early-stage triple-negative breast cancer predict prognosis and remodel the tumor immune microenvironment
por: Zhang, Jinguo, et al.
Publicado: (2023)

Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy
por: Wang, Qinghua, et al.
Publicado: (2020)

Predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer using multiparametric MRI
por: Lu, Nannan, et al.
Publicado: (2021)

Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma
por: Müller, Sarah, et al.
Publicado: (2021)

Evaluating distinct KRAS subtypes as potential biomarkers for immune checkpoint inhibitor efficacy in lung adenocarcinoma
por: Wang, Qi, et al.
Publicado: (2023)

Machine learning models based on immunological genes to predict the response to neoadjuvant therapy in breast cancer patients
por: Chen, Jian, et al.
Publicado: (2022)

Baseline Mutations and Up-Regulation of PI3K-AKT Pathway Serve as Potential Indicators of Lack of Response to Neoadjuvant Chemotherapy in Stage II/III Breast Cancer
por: Dong, Menghao, et al.
Publicado: (2022)

Unraveling the Role of Immune Checkpoints in Leishmaniasis
por: de Freitas e Silva, Rafael, et al.
Publicado: (2021)

Specific TP53 subtype as biomarker for immune checkpoint inhibitors in lung adenocarcinoma
por: Sun, Hao, et al.
Publicado: (2020)

Identification of Immune Subtypes of Esophageal Adenocarcinoma to Predict Prognosis and Immunotherapy Response
por: Ling, Chen, et al.
Publicado: (2022)

Identifying tumor antigens and immuno‐subtyping in colon adenocarcinoma to facilitate the development of mRNA vaccine
por: Tan, Huaicheng, et al.
Publicado: (2022)

Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment
por: Jiang, Yafei, et al.
Publicado: (2022)

Nimotuzumab Combined with Chemotherapy is a Promising Treatment for Locally Advanced and Metastatic Esophageal Cancer
por: Han, Xinghua, et al.
Publicado: (2017)

Identification of lung adenocarcinoma subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes
por: Hua, Linbin, et al.
Publicado: (2023)

The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations
por: Zheng, Difan, et al.
Publicado: (2016)

Macrophage-related molecular subtypes in lung adenocarcinoma identify novel tumor microenvironment with prognostic and therapeutic implications
por: Wen, Heng, et al.
Publicado: (2022)

Expression Patterns of Ezrin and AJAP1 and Clinical Significance in Breast Cancer
por: Xu, Cong, et al.
Publicado: (2022)

Deciphering the expression patterns of homologous recombination-related lncRNAs identifies new molecular subtypes and emerging therapeutic opportunities in epithelial ovarian cancer
por: Hua, Tian, et al.
Publicado: (2022)

Cuproptosis-related molecular subtypes direct T cell exhaustion phenotypes and therapeutic strategies for patients with lung adenocarcinoma
por: Zhu, Yi-Pan, et al.
Publicado: (2023)

Mining Database to Identify Aging-Related Molecular Subtype and Prognostic Signature in Lung Adenocarcinoma
por: Feng, Caihou, et al.
Publicado: (2022)

Expression Profiling Identifies Bezafibrate as Potential Therapeutic Drug for Lung Adenocarcinoma
por: Liu, Xinyan, et al.
Publicado: (2015)

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
por: Song, Xuming, et al.
Publicado: (2022)

FOXA1‐induced LINC00621 promotes lung adenocarcinoma progression via activating the TGF‐β signaling pathway
por: Wei, Jingjing, et al.
Publicado: (2023)

MicroRNA Landscape in Endometrial Carcinomas in an Asian population: Unraveling Subtype-Specific Signatures
por: Tan, Gideon Ze Lin, et al.
Publicado: (2023)

Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
por: Zhao, Xixian, et al.
Publicado: (2021)

Trastuzumab-induced thrombocytopenia after eight cycles of trastuzumab treatment
por: Zhou, Qiong, et al.
Publicado: (2020)

An autophagic gene‐based signature to predict the survival of patients with low‐grade gliomas
por: Chen, Jian, et al.
Publicado: (2021)

Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma
por: Chang, Xiaoyan, et al.
Publicado: (2022)

Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism
por: Schneider, Susanne A., et al.
Publicado: (2020)

Multi-omics analysis unravels the underlying mechanisms of poor prognosis and differential therapeutic responses of solid predominant lung adenocarcinoma
por: Li, Feng, et al.
Publicado: (2023)

Analysis of Lung Adenocarcinoma Subtypes Based on Immune Signatures Identifies Clinical Implications for Cancer Therapy
por: Xu, Feng, et al.
Publicado: (2020)

Unraveling tumour microenvironment heterogeneity in nasopharyngeal carcinoma identifies biologically distinct immune subtypes predicting prognosis and immunotherapy responses
por: Chen, Yu-Pei, et al.
Publicado: (2021)

NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas
por: Tlemsani, Camille, et al.
Publicado: (2019)

Novel immune subtypes of lung adenocarcinoma identified through bioinformatic analysis
por: Qin, Fang‐lu, et al.
Publicado: (2020)

Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma
por: Mahajan, Ujjwal Mukund, et al.
Publicado: (2021)

Core immune cell infiltration signatures identify molecular subtypes and promote precise checkpoint immunotherapy in cutaneous melanoma
por: Zhu, Zheng, et al.
Publicado: (2022)

Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma
por: Videla-Richardson, Guillermo A., et al.
Publicado: (2021)

Characterization of Necroptosis-Related Molecular Subtypes and Therapeutic Response in Lung Adenocarcinoma
por: Zhang, Jingchen, et al.
Publicado: (2022)

An Immune-Associated Genomic Signature Effectively Predicts Pathologic Complete Response to Neoadjuvant Paclitaxel and Anthracycline-Based Chemotherapy in Breast Cancer
por: Fu, Changfang, et al.
Publicado: (2021)

Significance of histologic subtype size as a prognostic indicator in stage IA lung adenocarcinoma
por: Jeon, Hyun Woo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_557lfbjetf0olocabpe4r6vdtl