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Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions

Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of new evidence makes it necessary to reconsider the subsets and treatment of AML patients with CEBPA mutations. This review will summarize th...

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Autores principales: Su, Long, Shi, Yuan-Yuan, Liu, Zeng-Yan, Gao, Su-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844020/
https://www.ncbi.nlm.nih.gov/pubmed/35178345
http://dx.doi.org/10.3389/fonc.2022.806137
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author Su, Long
Shi, Yuan-Yuan
Liu, Zeng-Yan
Gao, Su-Jun
author_facet Su, Long
Shi, Yuan-Yuan
Liu, Zeng-Yan
Gao, Su-Jun
author_sort Su, Long
collection PubMed
description Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of new evidence makes it necessary to reconsider the subsets and treatment of AML patients with CEBPA mutations. This review will summarize the history of research progress of CEBPA mutations in AML, the heterogeneities of AML with CEBPA double mutations (CEBPA(dm)), and two special subtypes of CEBPA mutated AML. We will discuss the treatment of AML with CEBPA mutations as well, and finally propose a new algorithm for the treatment of these patients, including both familial and sporadic CEBPA mutated AML patients. This review may be beneficial for further investigation and optimizing clinical management of AML patients with CEBPA mutations.
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spelling pubmed-88440202022-02-16 Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions Su, Long Shi, Yuan-Yuan Liu, Zeng-Yan Gao, Su-Jun Front Oncol Oncology Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of new evidence makes it necessary to reconsider the subsets and treatment of AML patients with CEBPA mutations. This review will summarize the history of research progress of CEBPA mutations in AML, the heterogeneities of AML with CEBPA double mutations (CEBPA(dm)), and two special subtypes of CEBPA mutated AML. We will discuss the treatment of AML with CEBPA mutations as well, and finally propose a new algorithm for the treatment of these patients, including both familial and sporadic CEBPA mutated AML patients. This review may be beneficial for further investigation and optimizing clinical management of AML patients with CEBPA mutations. Frontiers Media S.A. 2022-02-01 /pmc/articles/PMC8844020/ /pubmed/35178345 http://dx.doi.org/10.3389/fonc.2022.806137 Text en Copyright © 2022 Su, Shi, Liu and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Su, Long
Shi, Yuan-Yuan
Liu, Zeng-Yan
Gao, Su-Jun
Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title_full Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title_fullStr Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title_full_unstemmed Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title_short Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
title_sort acute myeloid leukemia with cebpa mutations: current progress and future directions
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844020/
https://www.ncbi.nlm.nih.gov/pubmed/35178345
http://dx.doi.org/10.3389/fonc.2022.806137
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