The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling

Inflammatory diseases decrease the extracellular environmental pH. However, whether proton-activated G protein-coupled receptors (GPCRs) can regulate the development of osteoarthritis (OA) is largely unknown. In this study, we report that proton-activated GPR4 is essential for OA development. We fou...

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Detalles Bibliográficos
Autores principales: Li, Rong, Guan, Zijing, Bi, Shuyan, Wang, Fanhua, He, Liang, Niu, Xin, You, Yu, Liu, Yuwei, Ding, Yi, Siwko, Stefan, Wang, Ning, Zhang, Ziming, Jin, Yunyun, Luo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844071/
https://www.ncbi.nlm.nih.gov/pubmed/35165253
http://dx.doi.org/10.1038/s41419-021-04455-4

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