Therapeutic peptides: current applications and future directions

Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcom...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Wang, Nanxi, Zhang, Wenping, Cheng, Xurui, Yan, Zhibin, Shao, Gang, Wang, Xi, Wang, Rui, Fu, Caiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844085/
https://www.ncbi.nlm.nih.gov/pubmed/35165272
http://dx.doi.org/10.1038/s41392-022-00904-4
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author Wang, Lei
Wang, Nanxi
Zhang, Wenping
Cheng, Xurui
Yan, Zhibin
Shao, Gang
Wang, Xi
Wang, Rui
Fu, Caiyun
author_facet Wang, Lei
Wang, Nanxi
Zhang, Wenping
Cheng, Xurui
Yan, Zhibin
Shao, Gang
Wang, Xi
Wang, Rui
Fu, Caiyun
author_sort Wang, Lei
collection PubMed
description Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications. We also discuss the value and challenges associated with future developments in therapeutic peptides.
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spelling pubmed-88440852022-02-18 Therapeutic peptides: current applications and future directions Wang, Lei Wang, Nanxi Zhang, Wenping Cheng, Xurui Yan, Zhibin Shao, Gang Wang, Xi Wang, Rui Fu, Caiyun Signal Transduct Target Ther Review Article Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications. We also discuss the value and challenges associated with future developments in therapeutic peptides. Nature Publishing Group UK 2022-02-14 /pmc/articles/PMC8844085/ /pubmed/35165272 http://dx.doi.org/10.1038/s41392-022-00904-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Lei
Wang, Nanxi
Zhang, Wenping
Cheng, Xurui
Yan, Zhibin
Shao, Gang
Wang, Xi
Wang, Rui
Fu, Caiyun
Therapeutic peptides: current applications and future directions
title Therapeutic peptides: current applications and future directions
title_full Therapeutic peptides: current applications and future directions
title_fullStr Therapeutic peptides: current applications and future directions
title_full_unstemmed Therapeutic peptides: current applications and future directions
title_short Therapeutic peptides: current applications and future directions
title_sort therapeutic peptides: current applications and future directions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844085/
https://www.ncbi.nlm.nih.gov/pubmed/35165272
http://dx.doi.org/10.1038/s41392-022-00904-4
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