Loss of circRNAs from the crh‐1 gene extends the mean lifespan in Caenorhabditis elegans

Accumulation of circular RNAs (circRNAs) during aging occurs on a genome‐wide level for multiple organisms, but its significance is unknown. Generating circRNA loss‐of‐function mutants is difficult because the vast majority of these RNAs are comprised of exons shared with protein‐coding mRNAs. In Ca...

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Detalles Bibliográficos
Autores principales: Knupp, David, Jorgensen, Brian G., Alshareef, Hussam Z., Bhat, Jaffar M., Grubbs, Jeremy J., Miura, Pedro, van der Linden, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844124/
https://www.ncbi.nlm.nih.gov/pubmed/35102684
http://dx.doi.org/10.1111/acel.13560

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