Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperatur...

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Autores principales: Ruan, Lifo, Chen, Jun, Du, Chuanchao, Lu, Huiru, Zhang, Jiayu, Cai, Xiaomeng, Dou, Rui, Lin, Wenchu, Chai, Zhifang, Nie, Guangjun, Hu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844157/
https://www.ncbi.nlm.nih.gov/pubmed/35224301
http://dx.doi.org/10.1016/j.bioactmat.2021.10.045
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author Ruan, Lifo
Chen, Jun
Du, Chuanchao
Lu, Huiru
Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Lin, Wenchu
Chai, Zhifang
Nie, Guangjun
Hu, Yi
author_facet Ruan, Lifo
Chen, Jun
Du, Chuanchao
Lu, Huiru
Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Lin, Wenchu
Chai, Zhifang
Nie, Guangjun
Hu, Yi
author_sort Ruan, Lifo
collection PubMed
description Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.
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spelling pubmed-88441572022-02-25 Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer Ruan, Lifo Chen, Jun Du, Chuanchao Lu, Huiru Zhang, Jiayu Cai, Xiaomeng Dou, Rui Lin, Wenchu Chai, Zhifang Nie, Guangjun Hu, Yi Bioact Mater Article Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance. KeAi Publishing 2021-11-04 /pmc/articles/PMC8844157/ /pubmed/35224301 http://dx.doi.org/10.1016/j.bioactmat.2021.10.045 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ruan, Lifo
Chen, Jun
Du, Chuanchao
Lu, Huiru
Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Lin, Wenchu
Chai, Zhifang
Nie, Guangjun
Hu, Yi
Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title_full Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title_fullStr Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title_full_unstemmed Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title_short Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
title_sort mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844157/
https://www.ncbi.nlm.nih.gov/pubmed/35224301
http://dx.doi.org/10.1016/j.bioactmat.2021.10.045
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