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Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults
Most people have a right-ear advantage for the perception of spoken syllables, consistent with left hemisphere dominance for speech processing. However, there is considerable variation, with some people showing left-ear advantage. The extent to which this variation is reflected in brain structure re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844177/ https://www.ncbi.nlm.nih.gov/pubmed/33502621 http://dx.doi.org/10.1007/s00429-021-02220-z |
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author | Guadalupe, Tulio Kong, Xiang-Zhen Akkermans, Sophie E. A. Fisher, Simon E. Francks, Clyde |
author_facet | Guadalupe, Tulio Kong, Xiang-Zhen Akkermans, Sophie E. A. Fisher, Simon E. Francks, Clyde |
author_sort | Guadalupe, Tulio |
collection | PubMed |
description | Most people have a right-ear advantage for the perception of spoken syllables, consistent with left hemisphere dominance for speech processing. However, there is considerable variation, with some people showing left-ear advantage. The extent to which this variation is reflected in brain structure remains unclear. We tested for relations between hemispheric asymmetries of auditory processing and of grey matter in 281 adults, using dichotic listening and voxel-based morphometry. This was the largest study of this issue to date. Per-voxel asymmetry indexes were derived for each participant following registration of brain magnetic resonance images to a template that was symmetrized. The asymmetry index derived from dichotic listening was related to grey matter asymmetry in clusters of voxels corresponding to the amygdala and cerebellum lobule VI. There was also a smaller, non-significant cluster in the posterior superior temporal gyrus, a region of auditory cortex. These findings contribute to the mapping of asymmetrical structure–function links in the human brain and suggest that subcortical structures should be investigated in relation to hemispheric dominance for speech processing, in addition to auditory cortex. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-021-02220-z. |
format | Online Article Text |
id | pubmed-8844177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88441772022-02-23 Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults Guadalupe, Tulio Kong, Xiang-Zhen Akkermans, Sophie E. A. Fisher, Simon E. Francks, Clyde Brain Struct Funct Original Article Most people have a right-ear advantage for the perception of spoken syllables, consistent with left hemisphere dominance for speech processing. However, there is considerable variation, with some people showing left-ear advantage. The extent to which this variation is reflected in brain structure remains unclear. We tested for relations between hemispheric asymmetries of auditory processing and of grey matter in 281 adults, using dichotic listening and voxel-based morphometry. This was the largest study of this issue to date. Per-voxel asymmetry indexes were derived for each participant following registration of brain magnetic resonance images to a template that was symmetrized. The asymmetry index derived from dichotic listening was related to grey matter asymmetry in clusters of voxels corresponding to the amygdala and cerebellum lobule VI. There was also a smaller, non-significant cluster in the posterior superior temporal gyrus, a region of auditory cortex. These findings contribute to the mapping of asymmetrical structure–function links in the human brain and suggest that subcortical structures should be investigated in relation to hemispheric dominance for speech processing, in addition to auditory cortex. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-021-02220-z. Springer Berlin Heidelberg 2021-01-27 2022 /pmc/articles/PMC8844177/ /pubmed/33502621 http://dx.doi.org/10.1007/s00429-021-02220-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Guadalupe, Tulio Kong, Xiang-Zhen Akkermans, Sophie E. A. Fisher, Simon E. Francks, Clyde Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title | Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title_full | Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title_fullStr | Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title_full_unstemmed | Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title_short | Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
title_sort | relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844177/ https://www.ncbi.nlm.nih.gov/pubmed/33502621 http://dx.doi.org/10.1007/s00429-021-02220-z |
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