DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells

The transcription factor hypoxia-inducible factor 1 (HIF1) is an important driver of cancer and is therefore an attractive drug target. Acriflavine (ACF) has been suggested to inhibit HIF1, but its mechanism of action is unknown. Here we investigated the interaction of ACF with DNA and long non-codi...

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Detalles Bibliográficos
Autores principales: Seredinski, Sandra, Boos, Frederike, Günther, Stefan, Oo, James A., Warwick, Timothy, Izquierdo Ponce, Judit, Lillich, Felix F., Proschak, Ewgenij, Knapp, Stefan, Gilsbach, Ralf, Pflüger-Müller, Beatrice, Brandes, Ralf P., Leisegang, Matthias S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844413/
https://www.ncbi.nlm.nih.gov/pubmed/35228897
http://dx.doi.org/10.1016/j.omtn.2022.01.016

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