Cargando…

In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems

SARS-CoV-2 is the causative agent of a new type of coronavirus infection, COVID-19, which has rapidly spread worldwide. The overall genome sequence homology between SARS-CoV-2 and SARS-CoV is 79%. However, the homology of the ORF8 protein between these two coronaviruses is low, at ~26%. Previously,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takatsuka, Hisashi, Fahmi, Muhamad, Hamanishi, Kotono, Sakuratani, Takuya, Kubota, Yukihiko, Ito, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844466/ https://www.ncbi.nlm.nih.gov/pubmed/35178414 http://dx.doi.org/10.3389/fmed.2022.824622

Ejemplares similares

The Functional Classification of ORF8 in SARS-CoV-2 Replication, Immune Evasion, and Viral Pathogenesis Inferred through Phylogenetic Profiling
por: Fahmi, Muhamad, et al.
Publicado: (2021)

Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab
por: Keng, Choong-Tat, et al.
Publicado: (2009)

Nonstructural proteins NS7b and NS8 are likely to be phylogenetically associated with evolution of 2019-nCoV
por: Fahmi, Muhamad, et al.
Publicado: (2020)

Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
por: Tang, Zhizhong, et al.
Publicado: (2023)

Immune evasion via SARS-CoV-2 ORF8 protein?
por: Park, Matthew D.
Publicado: (2020)

ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV
por: Zandi, Milad
Publicado: (2022)

SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence
por: Mohammad, Sameer, et al.
Publicado: (2020)

Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis
por: Shi, Yuheng, et al.
Publicado: (2020)

Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction
por: Chaudhari, Armi M., et al.
Publicado: (2022)

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein
por: Flower, Thomas G., et al.
Publicado: (2021)

Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein
por: Dawood, Ali Adel
Publicado: (2023)

Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein
por: Dawood, Ali Adel
Publicado: (2023)

Atypical Divergence of SARS-CoV-2 Orf8 from Orf7a within the Coronavirus Lineage Suggests Potential Stealthy Viral Strategies in Immune Evasion
por: Neches, Russell Y., et al.
Publicado: (2021)

ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion
por: Zandi, Milad
Publicado: (2022)

Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8
por: Flower, Thomas G., et al.
Publicado: (2021)

Crystallographic molecular replacement using an in silico‐generated search model of SARS‐CoV‐2 ORF8
por: Flower, Thomas G., et al.
Publicado: (2021)

SARS-CoV-2 ORF8: A Rapidly Evolving Immune and Viral Modulator in COVID-19
por: Arduini, Ariana, et al.
Publicado: (2023)

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
por: Li, Jin-Yan, et al.
Publicado: (2020)

C8ORF88: A Novel eIF4E-Binding Protein
por: Pugsley, Lauren, et al.
Publicado: (2023)

ORF8 and Health Complications of COVID-19 in Down Syndrome Patients
por: Bensussen, Antonio, et al.
Publicado: (2022)

Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation
por: Wu, Fang, et al.
Publicado: (2023)

Positive Selection of ORF1ab, ORF3a, and ORF8 Genes Drives the Early Evolutionary Trends of SARS-CoV-2 During the 2020 COVID-19 Pandemic
por: Velazquez-Salinas, Lauro, et al.
Publicado: (2020)

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021
por: Mazur-Panasiuk, Natalia, et al.
Publicado: (2021)

Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion
por: Flower, Thomas G., et al.
Publicado: (2020)

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
por: Zhang, Yiwen, et al.
Publicado: (2021)

Equid alphaherpesvirus 1 from Italian Horses: Evaluation of the Variability of the ORF30, ORF33, ORF34 and ORF68 Genes
por: Preziuso, Silvia, et al.
Publicado: (2019)

MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
por: Munasinghe, Thilini S., et al.
Publicado: (2022)

Norovirus Recombination in ORF1/ORF2 Overlap
por: Bull, Rowena A., et al.
Publicado: (2005)

PsORF: a database of small ORFs in plants
por: Chen, Yanjun, et al.
Publicado: (2020)

Author Correction: ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection
por: Hachim, Asmaa, et al.
Publicado: (2020)

The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein
por: Kumar, Purnima, et al.
Publicado: (2007)

Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses
por: Chen, Xiaoxue, et al.
Publicado: (2021)

Human Orf with Immune-Mediated Reactions: A Systematic Review
por: Rossi, Luca, et al.
Publicado: (2023)

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2
por: Zinzula, Luca
Publicado: (2021)

Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene
por: Pereira, Filipe
Publicado: (2020)

ORF8a as a viroporin in SARS-CoV-2 infection?
por: Zandi, Milad
Publicado: (2021)

Etymologia: Orf
Publicado: (2013)

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer
por: Matsuoka, Kazuhiro, et al.
Publicado: (2022)

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2
por: Su, Yvonne C. F., et al.
Publicado: (2020)

The Varicella-Zoster Virus ORF47 Kinase Interferes with Host Innate Immune Response by Inhibiting the Activation of IRF3
por: Vandevenne, Patricia, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9pvupgtn51g0qiv208m5omo78g